Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles and other materials authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2021

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A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration, Heather S. Loring, Victoria L. Czech, Janneke D. Icso, Lauren C. O'Connor, Sangram Parelkar, Alexandra B. Byrne, and Paul R. Thompson

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Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair, Anoushka Lotun, Dominic J. Gessler, and Guangping Gao

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Granulocytes act as a niche for Mycobacterium tuberculosis growth, Rustin R. Lovewell, Christina E. Baer, Bibhuti B. Mishra, Clare M. Smith, and Christopher M. Sassetti

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Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae, Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard E. Baker, and Allan Jacobson

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The 5 Pillars in Tourette Syndrome Deep Brain Stimulation Patient Selection: Present and Future, Davide Martino, Wissam Deeb, Joohi Jimenez-Shahed, Irene Malaty, Tamara M. Pringsheim, Alfonso Fasano, Christos Ganos, Winifred Wu, and Michael S. Okun

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NPWTi allows safe delayed free flap repair of Gustilo IIIb injuries: A prospective case series, Hajime Matsumine, Giorgio Giatsidis, Hiroshi Fujimaki, Nobuyuki Yoshimoto, Yuma Makino, Satoshi Hosoi, Mika Takagi, Mari Shimizu, and Masaki Takeuchi

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Oxybutynin treatment for buprenorphine-naloxone-induced hyperhidrosis, Lindsay McCormack, Joseph Ponce, Avik Chatterjee, and Jennifer K. Tan

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Stigma as a Barrier to Participant Recruitment of Minority Populations in Diabetes Research: Development of a Community-Centered Recruitment Approach, Suzanne Mitchell, Alexa Bragg, Ioana Moldovan, Shakiyla Woods, Katherine Melo, Jessica Martin-Howard, and Paula Gardiner

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The Effect of SMN Gene Dosage on ALS Risk and Disease Severity, Matthieu Moisse, John E. Landers, and Philip Van Damme

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Immune Response of Gamma-Irradiated Inactivated Bivalent Polio Vaccine Prepared plus Trehalose as a Protein Stabilizer in a Mouse Model, Maryam Mollaei Alamuti, Mehrdad Ravanshad, Farahnaz Motamedi-Sedeh, Arezoo Nabizadeh, Elham Ahmadi, and Seyedeh Maedeh Hossieni

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RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP), Laura Moreno-Leon, Emma L. West, Michelle O'Hara-Wright, Linjing Li, Rohini Nair, Jie He, Manisha Anand, Bhubanananda Sahu, Venkat Ramana Murthy Chavali, Alexander J. Smith, Robin R. Ali, Samuel G. Jacobson, Artur V. Cideciyan, and Hemant Khanna

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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE, Mona Motwani, Jason D. McGowan, Jennifer Antonovitch, Kevin MingJie Gao, Zhaozhao Jiang, Shrutie Sharma, Gretchen A. Baltus, Kevin M. Nickerson, Ann Marshak-Rothstein, and Katherine A. Fitzgerald

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Overcoming innate immune barriers that impede AAV gene therapy vectors, Manish Muhuri, Yukiko Maeda Garrison, Hong Ma, Sanjay Ram, Katherine A. Fitzgerald, Phillip W. L. Tai, and Guangping Gao

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Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction, Manish Muhuri, Wei Zhan, Yukiko Maeda Garrison, Jia Li, Anoushka Lotun, Jennifer Chen, Katelyn E. Sylvia, Ishani Dasgupta, Motahareh Arjomandnejad, Thomas Nixon, Allison M. Keeler, Sangeetha Manokaran, Ran He, Qin Su, Phillip W. L. Tai, and Guangping Gao

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JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging, Katrin Muller, Roger J. Davis, Achim Weber, and Tom Luedde

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Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance, Lara P. Murray, Ramesh Govindan, Andrea C. Mora, James B. Munro, and Charles R. Mace

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[Prevalence of diabetes mellitus and its complications and characterization of healthcare gaps based on triangulation of studies], Jessica Muzy, Monica Rodrigues Campos, Isabel Cristina Martins Emmerick, Raulino Sabino Silva da, and Joyce Mendes de Andrade Schramm

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Written Advice Given by African American Smokers to Their Peers: Qualitative Study of Motivational Messages, Catherine S. Nagawa, Jamie M. Faro, Anitha J. Menon, Mayuko Ito Fukunaga, Jessica H. Williams, Dalton Mourao, Oluwabunmi M. Emidio, Maryann Davis, Lori Pbert, Sarah L. Cutrona, Thomas K. Houston, and Rajani S. Sadasivam

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Effective Goals-of-Care Conversations: From Skills Training to Bedside, Vandana Nagpal, Mary Philbin, Majid Yazdani, Prashant Veerreddy, David Fish, and Jennifer Reidy

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Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A(b) in C57BL/6 Mouse Thymus, Padma P. Nanaware, Mollie M. Jurewicz, Cristina C. Clement, Liying Lu, Laura Santambrogio, and Lawrence J. Stern

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Genetic and spatial organization of the unusual chromosomes of the dinoflagellate Symbiodinium microadriaticum, Ankita Nand, Ye Zhan, Octavio R. Salazar, Manuel Aranda, Christian R. Voolstra, and Job Dekker

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The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, and David D. McManus

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A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA, Charles J. Nelson and Victor R. Ambros

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Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model, Catherine C. Neto, Benedikt M. Mortzfeld, John R. Turbitt, Shakti K. Bhattarai, Vladimir Yeliseyev, Nicholas DiBenedetto, Lynn Bry, and Vanni Bucci

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Impact of the COVID-19 pandemic on clinical research activities: Survey of study participants and health care workers participating in a hypertension trial in Vietnam, Hoa L. Nguyen, Oanh T. Tran, Duc A. Ha, Van H. Phan, Cuc T. Nguyen, Giang H. Nguyen, Thang T. Nguyen, German Chiriboga, Robert J. Goldberg, and Jeroan J. Allison

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Emerging Immunotherapies in the Treatment of Brain Metastases, Edwin Nieblas-Bedolla, Naema Nayyar, Mohini Singh, Ryan J. Sullivan, and Priscilla K. Brastianos

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Long-term GH Therapy Does Not Advance Skeletal Maturation in Children and Adolescents, Benjamin U. Nwosu, Gabrielle Jasmin, Sadichchha Parajuli, Alan D. Rogol, Ellen C. Wallace, and Austin F. Lee

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A Modified Version of the Transactional Stress Concept According to Lazarus and Folkman Was Confirmed in a Psychosomatic Inpatient Sample, Nina Obbarius, Felix Fischer, Gregor Liegl, Alexander Obbarius, and Matthias S. F. Rose

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Vaccines for human fungal diseases: close but still a long way to go, Lorena V. N. Oliveira, Ruiying Wang, Charles A. Specht, and Stuart M. Levitz

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Association Between Frailty and Atrial Fibrillation in Older Adults: The Framingham Heart Study Offspring Cohort, Ariela R. Orkaby, Jelena Kornej, Steven A. Lubitz, David D. McManus, Thomas G. Travison, Jason A. Sherer, Ludovic Trinquart, Joanne M. Murabito, Emelia J. Benjamin, and Sarah R. Preis

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Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice, Lena Ostermann, Regina Maus, Jennifer Stolper, Lisanne Schutte, Konstantina Katsarou, Srinu Tumpara, Andreas Pich, Christian Mueller, Sabina Janciauskiene, Tobias Welte, and Ulrich A. Maus

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Cranberry Proanthocyanidins and Dietary Oligosaccharides Synergistically Modulate Lactobacillus plantarum Physiology, Ezgi Ozcan, Michelle R. Rozycki, and David A. Sela

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Effect of Levodopa Initiation on the Gut Microbiota in Parkinson's Disease, Natalia Palacios, Anas Hannoun, Julie M. Flahive, Doyle V. Ward, Kelsey Goostrey, Anindita Deb, and Kara M. Smith

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Trabecular bone organoid model for studying the regulation of localized bone remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, and Jungwoo Lee

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Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection, Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George W. Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, and Sanjay Ram

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Adherence of Mobile App-Based Surveys and Comparison With Traditional Surveys: eCohort Study, Chathurangi H. Pathiravasan, David D. McManus, and Joanne M. Murabito

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Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques, Nuria Pedreno-Lopez, Brandon C. Rosen, Walter J. Flores, Matthew J. Gorman, Thomas B. Voigt, Michael J. Ricciardi, Kristin Crosno, Kim L. Weisgrau, Christopher L. Parks, Jeffrey D. Lifson, Galit Alter, Eva G. Rakasz, Diogo Magnani, Mauricio A. Martins, and David I. Watkins

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A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration, Camilla Pellegrini, Danielle Fernandes Durso, and Maria Giulia Bacalini

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Racial and Ethnic Differences in Managed Care Enrollment Among US Children, Alon Peltz, Kristin Kan, Arvin Garg, Alexander Pomerantz, Lucy A. Bilaver, and Matthew M. Davis

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, and Wen Xue

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Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease, Owen M. Peters, Alexandra Weiss, Jake P. Metterville, Lina Song, Robert Logan, Gaynor A. Smith, Michael A. Schwarzschild, Christian Mueller, Robert H. Brown Jr., and Marc R. Freeman

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BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model, Esteban Quezada, Claudio Cappelli, Ivan Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown Jr., Martin Montecino, and Brigitte van Zundert

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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia, Monica Reis, Gareth R. Willis, Angeles Fernandez-Gonzalez, Vincent Yeung, Elizabeth Taglauer, Margaret Magaletta, Teagan J. Parsons, Alan G. Derr, Xianlan Liu, Rene Maehr, Stella Kourembanas, and S. Alex Mitsialis

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Amputation Care Quality and Satisfaction With Prosthetic Limb Services: A Longitudinal Study of Veterans With Upper Limb Amputation, Linda Resnik, Matthew Borgia, Sarah Ekerholm, M. Jason Highsmith, Billie Jane Randolph, Joseph Webster, and Melissa A. Clark

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FLICK: an optimized plate reader-based assay to infer cell death kinetics, Ryan Richards, Megan E. Honeywell, and Michael J. Lee

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The molecular biology of FMRP: new insights into fragile X syndrome, Joel D. Richter and Xinyu Zhao

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The Clinical Review Committee: Impact of the Development of In Vitro Diagnostic Tests for SARS-CoV-2 Within RADx Tech, Matthew L. Robinson, Laura L. Gibson, and David D. McManus

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Maternal exposure to high-fat diet during pregnancy and lactation predisposes normal weight offspring mice to develop hepatic inflammation and insulin resistance, Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, and Jason K. Kim

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Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types, Sara Saez-Atienzar and John E. Landers

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The NIH Somatic Cell Genome Editing program, Krishanu Saha, Erik J. Sontheimer, Guangping Gao, Anastasia Khvorova, Jonathan K. Watts, and Scot A. Wolfe

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Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae, Sudeshna Saha, Sanjay Ram, and Ajit Varki

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Explaining Service Use and Residential Stability in Supported Housing: Problems, Preferences, Peers, Russell K. Schutt, Mark Schultz, Chantele Mitchell-Miland, Sharon McCarthy, Matthew Chinman, and Marsha Langer Ellison

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PFRED: A computational platform for siRNA and antisense oligonucleotides design, Simone Sciabola, Hualin Xi, Dario Cruz, Qing Cao, Christine Lawrence, Tianhong Zhang, Sergio Rotstein, Jason D. Hughes, Daniel R. Caffrey, and Robert V. Stanton

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An Unusual Case of Neurosyphilis Manifesting as Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), Hannah L. Seay, Loura Khallouf, Alyson Lieberman, and Sandeep Jubbal

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Prognostic Significance of Computed Tomography Findings in Pulmonary Vein Stenosis, Laureen Sena, Ryan Callahan, Lynn A. Sleeper, and Rebecca S. Beroukhim

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Study Design and Data Analysis of Artificial Pancreas Device Systems with Closed-Loop Glucose-Sensing Insulin Delivery, Sravya B. Shankara, Yujia Liu, Qingfeng Zheng, Jing Guo, Guixia Wang, and Bo Zhang

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The Emerging Global Tobacco Treatment Workforce: Characteristics of Tobacco Treatment Specialists Trained in Council-Accredited Training Programs from 2017 to 2019, Christine E. Sheffer and Caroline Cranos

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Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death, Lorissa J. Smulan, Nuria M. Martinez, Michael C. Kiritsy, Chido L. Kativhu, Kelly Cavallo, Christopher M. Sassetti, Amit Singhal, Heinz G. Remold, and Hardy Kornfeld

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Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines, Elliott D. SoRelle, Joanne Dai, Emmanuela N. Bonglack, Emma M. Heckenberg, Jeffrey Y. Zhou, Stephanie N. Giamberardino, Jeffrey A. Bailey, Simon G. Gregory, Cliburn Chan, and Micah A. Luftig

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Nox4 mediates skeletal muscle metabolic responses to exercise, Kalyn S. Specht, Shashi Kant, Heather Learnard, Maura Campbell, Amada D. Caliz, Yongmei Pei, Michaella M. Reif, John F. Keaney Jr., and Siobhan M. Craige

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Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility, Maya Spichal, Bree Heestand, Katherine Kretovich Billmyre, Stephen Frenk, Craig C. Mello, and Shawn Ahmed

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Unmet Medical Needs in the Treatment and Management of Generalized Pustular Psoriasis Flares: Evidence from a Survey of Corrona Registry Dermatologists, Bruce Strober, Nirali Kotowsky, Rose Medeiros, Rachel H. Mackey, Leslie R. Harrold, Wendell C. Valdecantos, Mary Flack, Amanda K. Golembesky, and Mark Lebwohl

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Transcutaneous carbon dioxide pattern and trend over time in preterm infants, Katherine P. Sullivan, Heather White, Lindsay E. Grover, Jordi J. Negron, Austin F. Lee, and Lawrence M. Rhein

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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program, Daniel Taliun, David D. McManus, L. Adrienne Cupples, Cathy C. Laurie, Cashell E. Jaquish, Ryan D. Hernandez, Timothy D. O'Connor, and Goncalo R. Abecasis

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Digital Health Information Disparities in Older Adults: a Mixed Methods Study, Ruth M. Tappen, Mary E. Cooley, Roger Luckmann, and Somi Panday

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Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants, Audrey Y-H. Teh, Lisa A. Cavacini, Yue Hu, Ozan S. Kumru, Jian Xiong, David T. Bolick, Sangeeta B. Joshi, Clemens Grunwald-Gruber, Friedrich Altmann, Mark S. Klempner, Richard L. Guerrant, David B. Volkin, Yang Wang, and Julian K-C. Ma

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Diagnostic accuracy of cardiac testing for coronary artery disease in potential liver transplant recipients: A systematic review and meta-analysis, Nidhish Tiwari, Jyothi Margapuri, Adarsh Katamreddy, Sandeep Jubbal, and Nidhi Madan

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Stakeholder-engaged process for refining the design of a clinical trial in home hospice, Jennifer Tjia, Margaret Clayton, German Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport, and Susan DeSanto-Madeya

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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML, Zuzana Tothova, Anne-Laure Valton, Sergey V. Venev, Job Dekker, and Benjamin L. Ebert

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An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals, Joseph F. Urban Jr, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, and Raffi V. Aroian

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Annotation of chromatin states in 66 complete mouse epigenomes during development, Arjan van der Velde, Kaili Fan, Junko Tsuji, Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, and Zhiping Weng

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Benign Tumors in Long-Term Survivors of Retinoblastoma, Milo van Hoefen Wijsard, Sara J. Schonfeld, Flora E. van Leeuwen, Annette C. Moll, Armida W. Fabius, David H. Abramson, Johanna M. Seddon, Jasmine H. Francis, Margaret A. Tucker, Ruth A. Kleinerman, and Lindsay M. Morton

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Histological assessment of developmental cell death in Drosophila pupae, Panagiotis D. Velentzas and Eric H. Baehrecke

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A 5-year clinical follow-up study from the Italian National Registry for FSHD, Liliana Vercelli, Louise Maranda, Tiziana Mongini, and Rossella Ginevra Tupler

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Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways, Christina Wagner, Neal S. Silverman, and Thomas Roeder

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Is this the end for ranitidine? NDMA presence continues to confound, Jennifer A. Wagner, Jean C. Dinh, Jenifer R. Lightdale, Benjamin D. Gold, and Jennifer M. Colombo

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Development and Validation of an Automated Algorithm to Detect Atrial Fibrillation Within Stored Intensive Care Unit Continuous Electrocardiographic Data: Observational Study, Allan J. Walkey, Syed K. Bashar, Md Billal. Hossain, Eric Y. Ding, Daniella Albuquerque, Michael Winter, Ki H. Chon, and David D. McManus

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Deficient spermiogenesis in mice lacking Rlim, Feng Wang, Maria Gracia Gervasi, Ana Boskovic, Fengyun Sun, Vera D. Rinaldi, Jun Yu, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando, Pablo E. Visconti, Lara Strittmatter, and Ingolf Bach

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Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial, Rene Westhovens and Jonathan Kay

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Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone, Antonia Wiegering, Renate Dildrop, Christine Vesque, Hemant Khanna, Sylvie Schneider-Maunoury, and Christoph Gerhardt

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CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features, Erik A. Williams, Meagan Montesion, Brian M. Alexander, Shakti H. Ramkissoon, Julia A. Elvin, Jeffrey S. Ross, Kevin Jon. Williams, Krzysztof Glomski, Jacob R. Bledsoe, Julie Y. Tse, and Mark C. Mochel

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Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis, Matthew F. Wipperman, Shakti K. Bhattarai, Charles Kyriakos Vorkas, Venkata Suhas Maringati, Ying Taur, Laurent Mathurin, Katherine McAulay, Stalz Charles Vilbrun, Daphie Francois, James Bean, Kathleen F. Walsh, Carl Nathan, Daniel W. Fitzgerald, Michael S. Glickman, and Vanni Bucci

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"I'm not gonna be able to do anything about it, then what's the point?": A broad group of stakeholders identify barriers and facilitators to HCV testing in a Massachusetts jail, Alysse G. Wurcel, Jessica Reyes, Julia Zubiago, Peter J. Koutoujian, Deirdre Burke, Tamsin A. Knox, Thomas Concannon, Stephenie C. Lemon, John B. Wong, Karen M. Freund, Curt G. Beckwith, and Amy M. LeClair

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Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion, Xun Wu, Yi-Shing Lisa Cheng, Mathew Matthen, Angela Yoon, Gary K. Schwartz, Shashi Bala, Alison M. Taylor, and Fatemeh Momen-Heravi

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Knowledge-based planning in robotic intracranial stereotactic radiosurgery treatments, Suhong Yu, Huijun Xu, Yin Zhang, Xin Zhang, Michael A. Dyer, Ariel E. Hirsch, Minh Tam Truong, and Heming Zhen

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A benchmark and an algorithm for detecting germline transposon insertions and measuring de novo transposon insertion frequencies, Tianxiong Yu, Xiao Huang, Shengqian Dou, Xiaolu Tang, Shiqi Luo, William E. Theurkauf, Jian Lu, and Zhiping Weng

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RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis, Matija Zelic, Boyao Zhang, M. Pontus A. Orning, Egil Lien, and Dimitry Ofengeim

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Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs, Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G. Clohessy, and Pier Paolo Pandolfi

Publications from 2020

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World Health Organization Guidelines on Treatment of Hepatitis C Virus Infection: Best Practice Advice From the American College of Physicians, George M. Abraham, Adam J. Obley, Linda L. Humphrey, and Amir Qaseem

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International observational atopic dermatitis cohort to follow natural history and treatment course: TARGET-DERM AD study design and rationale, Katrina Abuabara, Jonathan I. Silverberg, Eric L. Simpson, Amy S. Paller, Lawrence F. Eichenfield, Robert Bissonnette, James Krueger, John E. Harris, Laura Dalfonso, Stephanie E. Watkins, Julie M. Crawford, D. Thaci, and Emma Guttman-Yassky

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Modified CHA2DS2-VASc score predicts in-hospital mortality and procedural complications in acute coronary syndrome treated with percutaneous coronary intervention, Ashraf Abugroun, Abdalla Hassan, Safwan Gaznabi, Hakeem Ayinde, Ahmed Subahi, Mohammed Samee, Adhir Shroff, and Lloyd W. Klein

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Multimorbidity, physical frailty, and self-rated health in older patients with atrial fibrillation, Hawa Ozien Abu, Jane Saczynski, Jordy Mehawej, Tenes Paul, Hamza Awad, Benita A. Bamgbade, Isabelle C. Pierre-Louis, Mayra Tisminetzky, Catarina I. Kiefe, Robert J. Goldberg, and David D. McManus

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Clinically Meaningful Change in Quality of Life and Associated Factors Among Older Patients With Atrial Fibrillation, Hawa Ozien Abu, Jane S. Saczynski, Jordy Mehawej, Mayra Tisminetzky, Catarina I. Kiefe, Robert J. Goldberg, and David D. McManus

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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans, Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, and Katherine A. Fitzgerald

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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection, Federica Agliano, Katherine A. Fitzgerald, Anthony T. Vella, Vijay A. Rathinam, and Andrei E. Medvedev

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RNA Therapeutics Are Stepping Out of the Maze, Sudhir Agrawal

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Origami-Inspired Approaches for Biomedical Applications, Abdor Rahman Ahmed, Olivia C. Gauntlett, and Gulden Camci-Unal

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Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif, Zulfikar Ali, Vinuselvi Parisutham, Sandeep Choubey, and Robert C. Brewster

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A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux, Elizabeth A. Allen, Clelia Amato, Tina M. Fortier, Panagiotis D. Velentzas, Will Wood, and Eric H. Baehrecke

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Interchangeability of Biosimilars: What Level of Clinical Evidence is Needed to Support the Interchangeability Designation in the United States, Daniel F. Alvarez, Gertjan Wolbink, Carol Cronenberger, John Orazem, and Jonathan Kay