Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2017

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Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli, Sayali S. Karve, Suman Pradhan, Doyle V. Ward, and Alison A. Weiss

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Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys, Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, and Dan H. Barouch

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Diverse stimuli engage different neutrophil extracellular trap pathways, Elaine F. Kenny, Alf Herzig, Renate Krüger, Aaron Muth, Santanu Mondal, Paul R. Thompson, Volker Brinkmann, Horst Von Bernuth, and Arturo Zychlinsky

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Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments, Robert W. Kensler, Roger Craig, and Richard L. Moss

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Narrowing in on the anti-beta cell-specific T cells: looking 'where the action is', Sally C. Kent and Jenny Aurielle B. Babon

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Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, and Nils Henninger

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The chemical evolution of oligonucleotide therapies of clinical utility, Anastasia Khvorova and Jonathan K. Watts

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Acculturation, Depression, and Smoking Cessation: a trajectory pattern recognition approach, Sun S. Kim, Hua (Julia) Fang, Kunsook Bernstein, Zhaoyang Zhang, Joseph R. DiFranza, Douglas Ziedonis, and Jeroan J. Allison

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Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine, Cha San Koh, Rohini Madireddy, Timothy J. Beane, Phillip D. Zamore, and Andrei A. Korostelev

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Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics, Nigel G. Kooreman, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Joseph C. Wu

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Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy, Uchini S. Kosgodage, Rita P. Trindade, Paul R. Thompson, Jameel M. Inal, and Sigrun Lange

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Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography, Nicole Koulisis, Alice Y. Kim, Zhongdi Chu, Anoush Shahidzadeh, Bruce Burkemper, Lisa C. Olmos de Koo, Andrew A. Moshfeghi, Hossein Ameri, Carmen A. Puliafito, Veronica L. Isozaki, Ruikang K. Wang, and Amir H. Kashani

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Involvement of p38-betaTrCP-Tristetraprolin-TNFalpha axis in radiation pneumonitis, Pranathi Meda Krishnamurthy, Shirish Shukla, Paramita Ray, Rohit Mehra, Mukesh K. Nyati, Theodore S. Lawrence, and Dipankar Ray

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Recreational Physical Activity and Premenstrual Syndrome in Young Adult Women: A Cross-Sectional Study, Aimee R. Kroll-Desrosiers, Alayne G. Ronnenberg, Sofija E. Zagarins, Serena C. Houghton, Biki B. Takashima-Uebelhoer, and Elizabeth R. Bertone-Johnson

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Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review, Amy L. Kullas and Roger J. Davis

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The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis, Kyung J. Kwon-Chung, Stuart M. Levitz, and Arturo Casadevall

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A hemodialysis cohort study of protocol-based anticoagulation management, Steven Lamontagne, Tinzar Basein, Binyue Chang, and Lakshmi Mallela

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Self-consistent theory of transcriptional control in complex regulatory architectures, Jasper Landman, Robert C. Brewster, Franz M. Weinert, Rob Phillips, and Willem K. Kegel (PloS one, 7-7-2017)

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CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function, Lazaros Lataniotis, Andreas Albrecht, Fatma O. Kok, Clinton A. L. Monfries, Lorena Benedetti, Nathan D. Lawson, Simon M. Hughes, Kathleen Steinhofel, Manuel Mayr, and Anna Zampetaki

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The lysosomal protein cathepsin L is a progranulin protease, Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, and Leonard Petrucelli

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, , Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors, Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm, Charles P. Lin, Robert Sackstein, and Derrick J. Rossi

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Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell, Lei Lei, Radouil T. Tzekov, Huapeng Li, J. Hugh McDowell, Guangping Gao, W. Clay Smith, Shibo Tang, and Shalesh Kaushal

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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation, Jack L. Leonard, Deborah Marie Leonard, Scot A. Wolfe, Jilin Liu, Jaime A. Rivera-Perez, Michelle Yang, Ryan T. Leonard, Jacob P. S. Johnson, Prashant Kumar, Kate L. Liebmann, Amanda A. Tutto, Zhongming Mou, and Karl J. Simin

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New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model, Keith Limbach, Ann M. Moormann, and Joseph T. Bruder

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Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex, David L. Lin, Natalia A. Cherepanova, Leonia Bozzacco, Margaret R. MacDonald, Reid Gilmore, and Andrew W. Tai

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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension, Yeong Hann Ling, Shalini M. Krishnan, Christopher T. Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K. Kemp-Harper, Chrishan S. Samuel, Timothy D. Hewitson, Eicke Latz, Ashley Mansell, Christopher G. Sobey, and Grant R. Drummond

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Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study, Honghuang Lin, Xiaoyan Yin, Zhijun Xie, Kathryn L. Lunetta, Steven A. Lubitz, Martin G. Larson, Darae Ko, Jared W. Magnani, Michael M. Mendelson, Chunyu Liu, David D. McManus, Daniel Levy, Patrick T. Ellinor, and Emelia J. Benjamin

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Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis, Ziqiang Lin, James Neiswender, Bin Fang, Xuelei Ma, Jing Zhang, and Xiuying Hu

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Correlation between preconception maternal non-occupational exposure to interior decoration or oil paint odour and average birth weight of neonates: findings from a nationwide cohort study in China's rural areas, Huiting Liu, Shi Chen, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang, Bill Q. Lian, Chengsheng Yan, Jianqang Li, Qing Wang, Shikun Zhang, and Hui Pan

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Functional Gain and Pain Relief After Total Joint Replacement According to Obesity Status, Wenjun Li, David C. Ayers, Courtland G. Lewis, Thomas R. Bowen, Jeroan J. Allison, and Patricia D. Franklin

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Structural Analysis of the Glycosylated Intact HIV-1 gp120-b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting, Xiaoyan Li, Oliver C. Grant, Keigo Ito, Aaron Wallace, Shixia Wang, Peng Zhao, Lance Wells, Shan Lu, Robert J. Woods, and Joshua S. Sharp

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Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study, Michelle T. Long, Xiaoyan Yin, Martin G. Larson, Patrick T. Ellinor, Steven A. Lubitz, David D. McManus, Jared W. Magnani, Laila Staerk, Darae Ko, Robert H. Helm, Udo Hoffmann, Raymond T. Chung, and Emelia J. Benjamin

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Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo

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The role of heterogeneity in asthma: a structure-to-function perspective, Justin K. Lui and Kenneth R. Lutchen

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Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study, Angela Lupattelli, Mollie Wood, Kate L. Lapane, Olav Spigset, and Hedvig Nordeng

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization, Socheata Ly, Deanna M. Navaroli, Marie-Claire Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. Alterman, Kevin E. Fogarty, Clive Standley, Lawrence Lifshitz, Karl D. Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, and Anastasia Khvorova

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Use of distal perfusion in peripheral extracorporeal membrane oxygenation, George Makdisi, Tony Makdisi, and I-Wen Wang

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Ethical challenges and terminal deactivation of left ventricular assist device, Tony Makdisi and George Makdisi

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Ethical challenges in extra corporeal membrane oxygenation use, Tony Makdisi and George Makdisi

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Extra corporeal membrane oxygenation support: ethical dilemmas, Tony Makdisi and George Makdisi

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Frequency and Predictors of Self-Reported Hypoglycemia in Insulin-Treated Diabetes, Samir Malkani and Anupam Kotwal

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A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, and Benjamin U. Nwosu

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Oral Health and Medicine Integration: Overcoming Historical Artifact to Relieve Suffering, Stephen A. Martin and Lisa Simon

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The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

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Stakeholders' views on data sharing in multicenter studies, Kathleen M. Mazor, Allison Richards, Mia Gallagher, David E. Arterburn, Marsha A. Raebel, W. Benjamin Nowell, Jeffrey R. Curtis, Andrea R. Paolino, and Sengwee Toh

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Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia, Kate McArthur, Akshay A. D'Cruz, David Segal, Kurt Lackovic, Andrew F. Wilks, Joanne A. O'Donnell, Cameron J. Nowell, Motti Gerlic, David C. S. Huang, Christopher J. Burns, and Ben A. Croker

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Patient Use of Electronic Prescription Refill and Secure Messaging and Its Association With Undetectable HIV Viral Load: A Retrospective Cohort Study, D. Keith McInnes, Stephanie L. Shimada, Amanda M. Midboe, Kim M. Nazi, Shibei Zhao, Justina Wu, Casey M. Garvey, and Thomas K. Houston

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SipA Activation of Caspase-3 Is a Decisive Mediator of Host Cell Survival at Early Stages of Salmonella enterica Serovar Typhimurium Infection, Anne McIntosh, Lynsey M. Meikle, Michael J. Ormsby, Beth A. McCormick, John M. Christie, James M. Brewer, Mark Roberts, and Daniel M. Wall

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Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors, David D. McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J. Munson, Martin G. Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E. Freedman, and Daniel Levy

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Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models, Roly Megaw, Hashem Abu-Arafeh, Melissa Jungnickel, Carla Mellough, Christine Gurniak, Walter Witke, Wei Zhang, Hemant Khanna, Pleasantine Mill, Baljean Dhillon, Alan F. Wright, Majlinda Lako, and Charles Ffrench-Constant

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Screening of TNFalpha, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study, Angelica Mera-Ramirez, Andres Castillo, Yenifer Orobio, Maria Adelaida. Gomez, and Carolina Gallego-Marin

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Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance, Regino Mercado-Lubo and Beth A. McCormick

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Interleukin-36beta provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses, Katelynn A. Milora, Siva R. Uppalapati, Julio Sanmiguel, Wei Zou, and Liselotte E. Jensen

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Hdac3 regulates lymphovenous and lymphatic valve formation, , Zachary J. Milstone, Masahiro Shin, Nathan D. Lawson, John F. Keaney Jr., and Chinmay M. Trivedi

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Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair, Kenta Moriwaki, Sakthi Balaji, John Bertin, Peter J. Gough, and Francis Ka-Ming Chan

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Statistical analysis of genetic interactions in Tn-Seq data, , Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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Culturally adaptive storytelling intervention versus didactic intervention to improve hypertension control in Vietnam: a cluster-randomized controlled feasibility trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, and Robert J. Goldberg

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Ten-Year (2001-2011) Trends in the Incidence Rates and Short-Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction, Hoa L. Nguyen, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, David D. McManus, and Robert J. Goldberg

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Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness, Michiru Nishita, Seung-Yeol Park, Tadashi Nishio, Koki Kamizaki, ZhiChao Wang, Kota Tamada, Toru Takumi, Ryuju Hashimoto, Hiroki Otani, Gregory J. Pazour, Victor W. Hsu, and Yasuhiro Minami

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German translation, cultural adaptation, and validation of the Health Literacy Questionnaire (HLQ), Sandra Nolte, Richard H. Osborne, Sarah Dwinger, Gerald R. Elsworth, Melanie L. Conrad, Matthias S. F. Rose, Martin Harter, Jorg Dirmaier, and Jordis M. Zill

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Recombinant subunit vaccines for soil-transmitted helminths, Jason B. Noon and Raffi V. Aroian

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Vitamin D status in pediatric irritable bowel syndrome, Benjamin U. Nwosu, Louise Maranda, and Ninfa Candela

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Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma, Cliff I. Oduor, Mercedeh Movassagh, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John M. Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution, Louise Ormond, Ping Liu, Sebastian Matuszewski, Nicholas Renzette, Claudia Bank, Konstantin B. Zeldovich, Daniel N. Bolon, Timothy F. Kowalik, Robert W. Finberg, Jeffrey D. Jensen, and Jennifer P. Wang

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Decreased Functional Connectivity of Insular Cortex in Drug Naive First Episode Schizophrenia: In Relation to Symptom Severity, Lijuan Pang, David N. Kennedy, Qinling Wei, Luxian Lv, Jinsong Gao, Hong Li, Meina Quan, Xue Li, Yongfeng Yang, Xiaoduo Fan, and Xueqin Song

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Long-Term Effectiveness of Adalimumab in Patients with Rheumatoid Arthritis: An Observational Analysis from the Corrona Rheumatoid Arthritis Registry, Dimitrios A. Pappas, Joel M. Kremer, Jenny Griffith, George W. Reed, Bob Salim, Chitra Karki, and Vishvas Garg

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Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia, Christian M. Parobek, Jonathan B. Parr, Nicholas F. Brazeau, Chanthap Lon, Suwanna Chaorattanakawee, Panita Gosi, Eric J. Barnett, Lauren D. Norris, Steven R. Meshnick, Michele D. Spring, Charlotte A. Lanteri, Jeffrey A. Bailey, David L. Saunders, Jessica T. Lin, and Jonathan J. Juliano

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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration, Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, and Gregory J. Pazour

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Arteriovenous fistula patency in the 3 years following vonapanitase and placebo treatment, Eric K. Peden, Timothy P. O'Connor, Barry J. Browne, Bradley S. Dixon, Andres Schanzer, Stephen C. Jensik, Albert D. Sam 2nd, and Steven K. Burke

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Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA, Hannah M. Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J. Debacker, Michael P. Moazami, Vivek K. Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi, and Jonathan K. Watts

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Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice, Elizabeth M. Perez, Joslyn Foley, Timelia Tison, Rute Silva, and Javier Gordon Ogembo

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Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila, Ernesto Perez, Jillian L. Lindblad, and Andreas Bergmann

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High-Grade Partial and Retracted (less than 2 cm) Proximal Hamstring Ruptures: Nonsurgical Treatment Revisited, Jonathan R. Piposar, Amrit V. Vinod, Joshua R. Olsen, Edward Lacerte, and Suzanne L. Miller

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Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications, Cesar A. Prada-Medina, Kiyoshi F. Fukutani, Nathella Pavan Kumar, Leonardo Gil-Santana, Subash Babu, Flavio Lichtenstein, Kim West, Shanmugam Sivakumar, Pradeep A. Menon, Vijay Viswanathan, Bruno B. Andrade, Helder I. Nakaya, and Hardy Kornfeld

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Missing the target: including perspectives of women with overweight and obesity to inform stigma-reduction strategies, Rebecca M. Puhl, M. S. Himmelstein, A. A. Gorin, and Young J. Suh

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MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, and Brian C. Lewis

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Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq, Aurelie Quillien, Mary Abdalla, Jun Yu, Jianhong Ou, Lihua (Julie) Zhu, and Nathan D. Lawson

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Validity of the Nurses' health study physical activity questionnaire in estimating physical activity in adults with rheumatoid arthritis, Thomas Quinn, Michelle Frits, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt, and Maura D. Iversen

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Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Douglas Watson, Katherine Luzuriaga, George Siberry, Ann Petru, YaHui Chen, Priyanka Uprety, Margaret M. McManus, Ya-Chi Ho, Susanna L. Lamers, and Deborah Persaud

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Alcohol and Cancer: Mechanisms and Therapies, Anuradha Ratna and Pranoti Mandrekar

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Clinical and demographic factors associated with change and maintenance of disease severity in a large registry of patients with rheumatoid arthritis, George W. Reed, David H. Collier, Andrew S. Koenig, Katherine C. Saunders, Dimitrios A. Pappas, Heather J. Litman, Joel M. Kremer, and Sameer Kotak

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On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations, Nicholas Renzette, Susanne P. Pfeifer, Sebastian Matuszewski, Timothy F. Kowalik, and Jeffrey D. Jensen

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Overexpressed somatic alleles are enriched in functional elements in Breast Cancer, Paula Restrepo, Mercedeh Movassagh, Nawaf Alomran, Christian Miller, Muzi Li, Chris Trenkov, Yulian Manchev, Sonali Bahl, Stephanie Warnken, Liam Spurr, Tatiyana Apanasovich, Keith Crandall, Nathan Edwards, and Anelia Horvath

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Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model, Frederick R. Roberts, Clinton Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M. Van Dessel, Agata Jurczyk, David M. Harlan, Dale L. Greiner, Rita Bortell, and Chaoxing Yang

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ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation, Reddy Ranjith Kumar Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, and Daryl Bosco

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Beta-Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension, Mayank Sardana, Amer Ahmed Syed, Zeba Hashmath, Timothy S. Phan, Maheswara R. Koppula, Uzma Kewan, Zoubair Ahmed, Ravikantha Chandamuri, Swapna Varakantam, Ejaz Shah, Ryan Gorz, Scott R. Akers, and Julio A. Chirinos

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Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis, Partha Sardar, Amartya Kundu, Saurav Chatterjee, Anju Nohria, Ramez Nairooz, Sripal Bangalore, Debabrata Mukherjee, Wilbert S. Aronow, and Carl J. Lavie

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Patient safety during procedural sedation using capnography monitoring: a systematic review and meta-analysis, Rhodri Saunders, Michel M.R.F. Struys, Richard F. Pollock, Michael Mestek, and Jenifer R. Lightdale

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miRNAs cooperate in apoptosis regulation during C. elegans development, Ryan Sherrard, Sebastian Luehr, Heinke Holzkamp, Katherine McJunkin, Nadin Memar, and Barbara Conradt

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Atomistic structural ensemble refinement reveals non-native structure stabilizes a sub-millisecond folding intermediate of CheY, Jade Shi, R Paul. Nobrega, Christian Schwantes, Sagar V. Kathuria, Osman Bilsel, C. Robert Matthews, T J. Lane, and Vijay S. Pande

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Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer, Yoshifumi Shimada, Stephen Lyle, Kazuaki Takabe, and Toshifumi Wakai

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Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer, Yoshifumi Shimada, Stephen Lyle, and Toshifumi Wakai

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Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory, HyunMu Shin, Varun N. Kapoor, Gwanghun Kim, Peng Li, Hang-Rae Kim, M. Suresh, Susan M. Kaech, E. John Wherry, Liisa K. Selin, Warren J. Leonard, Raymond M. Welsh, and Leslie J. Berg

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Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism, Jihae Shin, Ki Young Paek, Mariya Ivshina, Emily E. Stackpole, and Joel D. Richter

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When Breath Becomes Air [book review], Hugh Silk

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A Hybrid III stepped wedge cluster randomized trial testing an implementation strategy to facilitate the use of an evidence-based practice in VA Homeless Primary Care Treatment Programs, Molly M. Simmons, Sonya Gabrielian, Thomas Hugh Byrne, Megan B. McCullough, Jeffery L. Smith, Thom J. Taylor, Thomas P. O'Toole, Vincent Kane, Vera Yakovchenko, D. Keith McInnes, and David A. Smelson