UMMS Affiliation

Division of Infectious Diseases and Immunology

Publication Date


Document Type



Animals; Membrane Glycoproteins; Mice; NADPH Oxidase; Neutrophils; Receptors, Cell Surface; Toll-Like Receptor 2; Toll-Like Receptors


Immunology and Infectious Disease


Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.

DOI of Published Version



J Clin Invest. 2003 Oct;112(8):1136-7. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical investigation

Related Resources

Link to Article in PubMed

PubMed ID




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