Center for Infectious Disease and Vaccine Research
Dengue; Dengue Virus; Humans; Immune System; Vaccines
Clinical Epidemiology | Immunology and Infectious Disease | Pharmacy and Pharmaceutical Sciences
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
DOI of Published Version
J Clin Invest. 2004 Apr;113(7):946-51. Link to article on publisher's site
The Journal of clinical investigation
Rothman, Alan L., "Dengue: defining protective versus pathologic immunity" (2004). Open Access Articles. 998.