Authors
Rothman, Alan L.UMass Chan Affiliations
Center for Infectious Disease and Vaccine ResearchDocument Type
Journal ArticlePublication Date
2004-04-02Keywords
DengueDengue Virus
Humans
Immune System
Vaccines
Clinical Epidemiology
Immunology and Infectious Disease
Pharmacy and Pharmaceutical Sciences
Metadata
Show full item recordAbstract
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.Source
J Clin Invest. 2004 Apr;113(7):946-51. Link to article on publisher's siteDOI
10.1172/JCI21512Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42671PubMed ID
15057297Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1172/JCI21512