Department of Pathology; Department of Molecular Genetics and Microbiology
Animals; Antibodies, Viral; Humans; Membrane Glycoproteins; Mice; Neutralization Tests; RNA, Viral; Viral Envelope Proteins; Virion
Medical Pathology | Microbiology | Molecular Genetics
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
DOI of Published Version
J Clin Invest. 2004 Oct;114(7):895-7. Link to article on publisher's site
The Journal of clinical investigation
Szomolanyi-Tsuda, Eva and Welsh, Raymond M., "Judging a virus by its cover" (2004). Open Access Articles. 997.