Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton
Department of Cell Biology
Actins; *Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; COS Cells; Carrier Proteins; Cloning, Molecular; Dynamin I; Dynamins; GTP Phosphohydrolases; Nerve Tissue Proteins; Precipitin Tests; Protein Binding; Protein Isoforms; Synapses; Two-Hybrid System Techniques
Life Sciences | Medicine and Health Sciences
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.
DOI of Published Version
J Biol Chem. 2001 Dec 21;276(51):48458-65. Epub 2001 Oct 2. Link to article on publisher's site
The Journal of biological chemistry
Okamoto, Patricia M.; Gamby, Chantal; Wells, David G.; Fallon, Justin R.; and Vallee, Richard B., "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton" (2001). Open Access Articles. 735.