Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression
Program in Molecular Medicine
Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Survival; DNA Replication; G1 Phase; G2 Phase; Hela Cells; Histones; Humans; Intranuclear Space; Motor Neurons; Nuclear Proteins; Organelles; S Phase; *Transcription, Genetic; Zinc Fingers
Life Sciences | Medicine and Health Sciences
The zinc finger protein ZPR1 is present in both the cytoplasm and nucleoplasm. Cell cycle analysis demonstrates that ZPR1 undergoes major changes in subcellular distribution during proliferation. ZPR1 is diffusely localized throughout the cell during the G(1) and G(2)/M phases of the cell cycle. In contrast, ZPR1 redistributes to the nucleus during S phase and ZPR1 exhibits prominent co-localization with the survival motor neurons protein and the histone gene-specific transcription factor NPAT in subnuclear foci, including Cajal bodies that associate with histone gene clusters. ZPR1 deficiency causes disruption of survival motor neurons and NPAT localization within the nucleus, blocks S phase progression, and arrests cells in both the G(1) and G(2) phases of the cell cycle. These changes in subnuclear architecture and cell cycle progression may be caused by transcriptional defects in ZPR1-deficient cells, including decreased histone gene expression.
DOI of Published Version
J Biol Chem. 2006 Dec 29;281(52):40330-40. Epub 2006 Oct 26. Link to article on publisher's site
The Journal of biological chemistry
Gangwani, Laxman, "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression" (2006). Open Access Articles. 673.