UMMS Affiliation

Program in Molecular Medicine

Publication Date


Document Type



Adolescent; Aged; Amino Acid Sequence; Animals; Base Sequence; Child, Preschool; Drosophila; Female; Hela Cells; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mitogens; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Serine-Threonine Kinases; purification; Recombinant Fusion Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity


Biochemistry | Cell Biology | Developmental Biology | Molecular Biology


Although the ultimate targets of many signal transduction pathways are nuclear transcription factors, the vast majority of known protein kinases are cytosolic. Here, we report on a novel human kinase that is present exclusively in the nucleus. Kinase activity is increased upon cellular proliferation and is markedly elevated in patients with acute and chronic lymphocytic leukemias. We have identified a human gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity. Collectively, these results suggest that this nuclear kinase is a component of a signal transduction pathway that plays a role in Drosophila development and human growth control.


Signal transduction, kinases, Drosophila, leukemia, trithorax]

Rights and Permissions

© 1996 by Cold Spring Harbor Laboratory Press. Publisher PDF posted as allowed by the publisher's license to publish at

DOI of Published Version



Genes Dev. 1996 Feb 1;10(3):261-71. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development

Related Resources

Link to Article in PubMed

PubMed ID




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