A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator
Howard Hughes Medical Institute; Program in Molecular Medicine; Program in Gene Function and Expression
Adolescent; Aged; Amino Acid Sequence; Animals; Base Sequence; Child, Preschool; Drosophila; Female; Hela Cells; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mitogens; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Serine-Threonine Kinases; purification; Recombinant Fusion Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity
Life Sciences | Medicine and Health Sciences
Although the ultimate targets of many signal transduction pathways are nuclear transcription factors, the vast majority of known protein kinases are cytosolic. Here, we report on a novel human kinase that is present exclusively in the nucleus. Kinase activity is increased upon cellular proliferation and is markedly elevated in patients with acute and chronic lymphocytic leukemias. We have identified a human gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity. Collectively, these results suggest that this nuclear kinase is a component of a signal transduction pathway that plays a role in Drosophila development and human growth control.
Genes Dev. 1996 Feb 1;10(3):261-71.
Genes and development
Denis, Gerald V. and Green, Michael R., "A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator" (1996). Open Access Articles. 598.