Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics
Program in Molecular Medicine
Adenosine Triphosphate; Animals; Chromatin; DNA; Drosophila Proteins; Gene Expression Regulation; Histones; Humans
Life Sciences | Medicine and Health Sciences
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA-histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be 'tamed' by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
DOI of Published Version
EMBO Rep. 2002 Apr;3(4):319-22. Link to article on publisher's site
Peterson CL. (2002). Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics. Open Access Articles. https://doi.org/10.1093/embo-reports/kvf075. Retrieved from https://escholarship.umassmed.edu/oapubs/510