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Authors
Shaw, Leslie M.UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Response or CommentPublication Date
2021-09-24
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TANK-binding kinase 1 (TBK1) is a noncanonical IkappaB kinase that plays an essential role in the innate immune response to foreign pathogens. Recent studies have highlighted additional roles for TBK1 in the regulation of metabolism, although the mechanisms of this regulation have not been well characterized. In a recent issue, Tooley et al. demonstrated that TBK1-dependent activation of downstream kinase Akt is mediated via mechanistic target of rapamycin complex 2. This novel action of TBK1 reveals a key role for this kinase in the regulation of cellular metabolism and growth by diverse environmental inputs.Source
Shaw LM. TBK1 has a new Akt. J Biol Chem. 2021 Oct;297(4):101244. doi: 10.1016/j.jbc.2021.101244. Epub 2021 Sep 24. PMID: 34563542; PMCID: PMC8498460. Link to article on publisher's site
DOI
10.1016/j.jbc.2021.101244Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42712PubMed ID
34563542Related Resources
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Copyright © 2021 The Author. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.jbc.2021.101244
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Except where otherwise noted, this item's license is described as Copyright © 2021 The Author. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).