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Department of Molecular, Cell and Cancer Biology

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Biochemistry, Biophysics, and Structural Biology


TANK-binding kinase 1 (TBK1) is a noncanonical IkappaB kinase that plays an essential role in the innate immune response to foreign pathogens. Recent studies have highlighted additional roles for TBK1 in the regulation of metabolism, although the mechanisms of this regulation have not been well characterized. In a recent issue, Tooley et al. demonstrated that TBK1-dependent activation of downstream kinase Akt is mediated via mechanistic target of rapamycin complex 2. This novel action of TBK1 reveals a key role for this kinase in the regulation of cellular metabolism and growth by diverse environmental inputs.

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Copyright © 2021 The Author. This is an open access article under the CC BY license (

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Shaw LM. TBK1 has a new Akt. J Biol Chem. 2021 Oct;297(4):101244. doi: 10.1016/j.jbc.2021.101244. Epub 2021 Sep 24. PMID: 34563542; PMCID: PMC8498460. Link to article on publisher's site

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The Journal of biological chemistry

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.