CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection
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Authors
Lu, Yu-JungBarreira-Silva, Palmira
Boyce, Shayla
Powers, Jennifer
Cavallo, Kelly
Behar, Samuel M.
Student Authors
Yu-Jung LuAcademic Program
Immunology and MicrobiologyUMass Chan Affiliations
Microbiology and Physiological SystemsGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2021-09-14Keywords
CD4 T cell helpCD4 T cells
CD8 T cells
CTL
T cell exhaustion
immunity
infection
interferon gamma
lung
mycobacterium tuberculosis
Bacterial Infections and Mycoses
Immunology and Infectious Disease
Microbiology
Metadata
Show full item recordAbstract
CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-gamma. Whether CD4 T cells act as "helper" cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and CD8 T cells in promoting the survival of infected mice. Purified helped, but not helpless, CD8 T cells efficiently restrict intracellular bacterial growth in vitro. Thus, CD4 T cell help plays an essential role in generating protective CD8 T cell responses against M. tuberculosis infection in vitro and in vivo. We infer vaccines that elicit both CD4 and CD8 T cells are more likely to be successful than vaccines that elicit only CD4 or CD8 T cells.Source
Lu YJ, Barreira-Silva P, Boyce S, Powers J, Cavallo K, Behar SM. CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection. Cell Rep. 2021 Sep 14;36(11):109696. doi: 10.1016/j.celrep.2021.109696. PMID: 34525366; PMCID: PMC8466141. Link to article on publisher's site
DOI
10.1016/j.celrep.2021.109696Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42688PubMed ID
34525366Related Resources
This article is based on a previously available preprint in bioRxiv, https://doi.org/10.1101/2021.02.23.432461.Rights
Copyright 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2021.109696
Scopus Count
Except where otherwise noted, this item's license is described as Copyright 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).