UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2021-08-31

Document Type

Editorial

Disciplines

Microbiology

Abstract

The human microbiome constitutes the collection of all the microorganisms living in association with the human body with each body site being home to a unique microbial community. Human-associated microbial communities can include eukaryotes, archaea, bacteria, and viruses and provide protection against foreign invaders, stimulate the immune response, produce antimicrobials, and aid in digestion among other functions. Our understanding of the link between the human microbiome and disease is rapidly expanding in large part due to revolutionizing advances in next generation sequencing. In fact, an ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states or responses to treatment. However, understanding the impact of shifts in microbial communities on health and disease and the mechanisms that confer stability in the microbiome have been challenging to elucidate, due to the vast microbial diversity and differences between individuals. Nevertheless, the notion that manipulation of microbial communities may provide prophylactic or therapeutic tools to improve human health has been the focus of much research. Here, we highlight a collection of Pearls articles delving into the current state of knowledge linking the microbiome to human disease.

Keywords

Microbiome, Fungi, Gastrointestinal cancers, Gut bacteria, RNA viruses, Respiratory syncytial virus, Eukaryota, Host-pathogen interactions

Rights and Permissions

Copyright © 2021 Hogan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI of Published Version

10.1371/journal.ppat.1009912

Source

Hogan DA, Heitman J, Jabra-Rizk MA, Knoll LJ, Leong JM, Silverman N. Editorial overview of Pearls Microbiome Series: E pluribus unum. PLoS Pathog. 2021 Aug 31;17(8):e1009912. doi: 10.1371/journal.ppat.1009912. PMID: 34464427; PMCID: PMC8407538. Link to article on publisher's site

Journal/Book/Conference Title

PLoS pathogens

Related Resources

Link to Article in PubMed

PubMed ID

34464427

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Included in

Microbiology Commons

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