Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins
UMass Chan Affiliations
Department of Pharmacology and Molecular ToxicologyWorcester Foundation for Biomedical Research
Document Type
Journal ArticlePublication Date
1999-06-01Keywords
AnimalsBiotransformation
Catechols
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Estrogen Antagonists
Humans
Hydroxylation
Liver
Mixed Function Oxygenases
Pentobarbital
Protein Binding
Rats
Rats, Sprague-Dawley
Tamoxifen
Biochemistry, Biophysics, and Structural Biology
Life Sciences
Medicine and Health Sciences
Pharmacology, Toxicology and Environmental Health