TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking
Department of Neurology
Neuroscience and Neurobiology
TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.
ALS, FTD, Membrane trafficking, Neurons, TBK 1, iPSC
DOI of Published Version
Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site
Lu Y, Almeida S, Gao F. (2021). TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Open Access Publications by UMass Chan Authors. https://doi.org/10.1007/s00401-021-02331-1. Retrieved from https://escholarship.umassmed.edu/oapubs/4820