Title

TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking

UMMS Affiliation

Department of Neurology

Publication Date

2021-07-01

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.

Keywords

ALS, FTD, Membrane trafficking, Neurons, TBK 1, iPSC

DOI of Published Version

10.1007/s00401-021-02331-1

Source

Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site

Journal/Book/Conference Title

Acta neuropathologica

Related Resources

Link to Article in PubMed

PubMed ID

34081168

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