Department of Pediatrics
Response or Comment
Bioethics and Medical Ethics | Pediatrics | Psychiatry and Psychology | Therapeutics
I am writing about the paper “Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder” by Thanh et al, first published September 9, 2020 in STEM CELLS Translational Medicine.
As a pediatrician who cares for autistic children, I have grave concerns about this paper. This paper does not describe valid research but rather details the abuse of disabled children. For one, the authors did not inject stem cells—they injected mononuclear bone marrow cells. They did not report on how many stem cells are in their preparation. Furthermore, injecting anything intrathecally can have serious consequences, including the development of lifelong pain (arachnoiditis) or bleeding into the spinal cord causing paralysis. Such a risky intervention should only be considered if the alternative of no treatment is more dire. Autism is not a dire sentence. There are alternative effective therapies for autism. Subjecting children, without their consent, to a seriously risky procedure is abuse. Forty‐eight percent of the children have side effects, including pain. I do not consider pain a minor adverse event; I consider it major and related to the study. Furthermore, these are disabled children and are a protected vulnerable group in whom research should only be performed if it is of likely/potential benefit and poses minimal risk. In the United States, I doubt this study would be approved by an internal review board.
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Copyright © 2021 The Author. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
DOI of Published Version
Finlay-Morreale H. Invasive therapy for children with autism is not justified. Stem Cells Transl Med. 2021 Jun;10(6):826. doi: 10.1002/sctm.20-0434. PMID: 34010521; PMCID: PMC8133346. Link to article on publisher's site
Stem cells translational medicine
Finlay-Morreale H. (2021). Invasive therapy for children with autism is not justified. Open Access Publications by UMass Chan Authors. https://doi.org/10.1002/sctm.20-0434. Retrieved from https://escholarship.umassmed.edu/oapubs/4818
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