Department of Psychiatry
Cognitive Neuroscience | Developmental Neuroscience | Pediatrics
The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.
Adolescent brain cognitive development study, Covariate Adjustments, Effect Sizes, Genetics, Hypothesis testing, Population neuroscience, Reproducibility
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© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/)
DOI of Published Version
Dick AS, Lopez DA, Watts AL, Heeringa S, Reuter C, Bartsch H, Fan CC, Kennedy DN, Palmer C, Marshall A, Haist F, Hawes S, Nichols TE, Barch DM, Jernigan TL, Garavan H, Grant S, Pariyadath V, Hoffman E, Neale M, Stuart EA, Paulus MP, Sher KJ, Thompson WK. Meaningful associations in the adolescent brain cognitive development study. Neuroimage. 2021 Oct 1;239:118262. doi: 10.1016/j.neuroimage.2021.118262. Epub 2021 Jun 18. PMID: 34147629. Link to article on publisher's site
Dick AS, Kennedy DN, Jernigan TL, Thompson WK. (2021). Meaningful associations in the adolescent brain cognitive development study. Open Access Publications by UMass Chan Authors. https://doi.org/10.1016/j.neuroimage.2021.118262. Retrieved from https://escholarship.umassmed.edu/oapubs/4813
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