Title

Differences in survival among multiple myeloma patients in the United States SEER population by neighborhood socioeconomic status and race/ethnicity

UMMS Affiliation

Department of Population and Quantitative Health Sciences; Meyers Primary Care Institute; Department of Medicine

Publication Date

2021-09-01

Document Type

Article

Disciplines

Epidemiology | Neoplasms | Race and Ethnicity

Abstract

PURPOSE: We examined the combined influences of race/ethnicity and neighborhood socioeconomic status (SES) on long-term survival among patients with multiple myeloma (MM).

METHODS: Data from the 2000-2015 NCI Surveillance, Epidemiology, and End Results Program (SEER-18) were used. Census tract-level SES index was assessed in tertiles (low, medium, high SES). Competing-risk modeling was used to estimate sub-hazard ratios (SHR) and 95% confidence intervals (CIs) for SES tertile adjusted for sex and age at diagnosis and stratified by race/ethnicity.

RESULTS: Overall, living in a low SES neighborhood was associated with worse MM survival. However, we observed some variation in the association by racial/ethnic group. Living in a low versus a high SES neighborhood was associated with a 35% (95% CI = 1.16-1.57) increase in MM-specific mortality risk among Asian/Pacific Islander cases, a 17% (95% CI = 1.12-1.22) increase among White cases, a 14% (95% CI = 1.04-1.23) increase among Black cases, and a 7% (95% CI = 0.96-1.19) increase among Hispanic cases.

CONCLUSION: These results suggest that the influence of both SES and race/ethnicity should be considered when considering interventions to remedy disparities in MM survival.

Keywords

Multiple myeloma, Race/ethnicity, Socioeconomic status, Survival, UMCCTS funding

DOI of Published Version

10.1007/s10552-021-01454-w

Source

Castañeda-Avila MA, Jesdale BM, Beccia A, Bey GS, Epstein MM. Differences in survival among multiple myeloma patients in the United States SEER population by neighborhood socioeconomic status and race/ethnicity. Cancer Causes Control. 2021 Sep;32(9):1021-1028. doi: 10.1007/s10552-021-01454-w. Epub 2021 Jun 5. PMID: 34089470; PMCID: PMC8316426. Link to article on publisher's site

Journal/Book/Conference Title

Cancer causes and control : CCC

Related Resources

Link to Article in PubMed

PubMed ID

34089470

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