Division of Infectious Diseases and Immunology, Department of Medicine; Graduate School of Biomedical Sciences
Hemic and Lymphatic Diseases | Immune System Diseases | Immunology of Infectious Disease | Immunopathology | International Public Health | Neoplasms | Pediatrics | Virus Diseases
Endemic Burkitt lymphoma (eBL) is an aggressive pediatric B cell lymphoma, common in Equatorial Africa. Co-infections with Epstein-Barr virus (EBV) and Plasmodium falciparum, coupled with c-myc translocation are involved in eBL etiology. Infection-induced immune evasion mechanisms to avoid T cell cytotoxicity may increase the role of Natural killer (NK) cells in anti-tumor immunosurveillance. Killer immunoglobulin-like receptor (KIR) genes on NK cells exhibit genotypic and allelic variations and are associated with susceptibility to diseases and malignancies. However, their role in eBL pathogenesis remains undefined. This retrospective study genotyped sixteen KIR genes and compared their frequencies in eBL patients (n = 104) and healthy geographically-matched children (n = 104) using sequence-specific primers polymerase chain reaction (SSP-PCR) technique. The relationship between KIR polymorphisms with EBV loads and eBL pathogenesis was investigated. Possession of > /= 4 activating KIRs predisposed individuals to eBL (OR = 3.340; 95% CI 1.530-7.825; p = 0.004). High EBV levels were observed in Bx haplogroup (p = 0.016) and AB genotypes (p = 0.042) relative to AA haplogroup and AA genotype respectively, in eBL patients but not in healthy controls. Our results suggest that KIR-mediated NK cell stimulation could mute EBV control, contributing to eBL pathogenesis.
Cancer, Immunology, Molecular biology
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DOI of Published Version
Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM. Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. Sci Rep. 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753; PMCID: PMC8166913. Link to article on publisher's site
Muriuki BM, Forconi C, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM. (2021). Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. Open Access Publications by UMMS Authors. https://doi.org/10.1038/s41598-021-90596-7. Retrieved from https://escholarship.umassmed.edu/oapubs/4764
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Hemic and Lymphatic Diseases Commons, Immune System Diseases Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, International Public Health Commons, Neoplasms Commons, Pediatrics Commons, Virus Diseases Commons