UMMS Affiliation
Division of Infectious Diseases and Immunology, Department of Medicine; Graduate School of Biomedical Sciences
Publication Date
2021-05-31
Document Type
Article
Disciplines
Hemic and Lymphatic Diseases | Immune System Diseases | Immunology of Infectious Disease | Immunopathology | International Public Health | Neoplasms | Pediatrics | Virus Diseases
Abstract
Endemic Burkitt lymphoma (eBL) is an aggressive pediatric B cell lymphoma, common in Equatorial Africa. Co-infections with Epstein-Barr virus (EBV) and Plasmodium falciparum, coupled with c-myc translocation are involved in eBL etiology. Infection-induced immune evasion mechanisms to avoid T cell cytotoxicity may increase the role of Natural killer (NK) cells in anti-tumor immunosurveillance. Killer immunoglobulin-like receptor (KIR) genes on NK cells exhibit genotypic and allelic variations and are associated with susceptibility to diseases and malignancies. However, their role in eBL pathogenesis remains undefined. This retrospective study genotyped sixteen KIR genes and compared their frequencies in eBL patients (n = 104) and healthy geographically-matched children (n = 104) using sequence-specific primers polymerase chain reaction (SSP-PCR) technique. The relationship between KIR polymorphisms with EBV loads and eBL pathogenesis was investigated. Possession of > /= 4 activating KIRs predisposed individuals to eBL (OR = 3.340; 95% CI 1.530-7.825; p = 0.004). High EBV levels were observed in Bx haplogroup (p = 0.016) and AB genotypes (p = 0.042) relative to AA haplogroup and AA genotype respectively, in eBL patients but not in healthy controls. Our results suggest that KIR-mediated NK cell stimulation could mute EBV control, contributing to eBL pathogenesis.
Keywords
Cancer, Immunology, Molecular biology
Rights and Permissions
Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/s41598-021-90596-7
Source
Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM. Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. Sci Rep. 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753; PMCID: PMC8166913. Link to article on publisher's site
Journal/Book/Conference Title
Scientific reports
Related Resources
PubMed ID
34059753
Repository Citation
Muriuki BM, Forconi C, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM. (2021). Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. Open Access Publications by UMMS Authors. https://doi.org/10.1038/s41598-021-90596-7. Retrieved from https://escholarship.umassmed.edu/oapubs/4764
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Hemic and Lymphatic Diseases Commons, Immune System Diseases Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, International Public Health Commons, Neoplasms Commons, Pediatrics Commons, Virus Diseases Commons