UMMS Affiliation

Division of Infectious Diseases, Department of Medicine; Graduate School of Biomedical Sciences

Publication Date

2021-05-04

Document Type

Article

Disciplines

Hemic and Lymphatic Diseases | Immune System Diseases | Immunology of Infectious Disease | Immunopathology | Infectious Disease | Virus Diseases | Viruses

Abstract

Herpesvirus infections shape the human natural killer (NK) cell compartment. While Epstein-Barr virus (EBV) expands immature NKG2A(+) NK cells, human cytomegalovirus (CMV) drives accumulation of adaptive NKG2C(+) NK cells. Kaposi sarcoma-associated herpesvirus (KSHV) is a close relative of EBV, and both are associated with lymphomas, including primary effusion lymphoma (PEL), which nearly always harbors both viruses. In this study, KSHV dual infection of mice with reconstituted human immune system components leads to the accumulation of CD56(-)CD16(+)CD38(+)CXCR6(+) NK cells. CD56(-)CD16(+) NK cells were also more frequently found in KSHV-seropositive Kenyan children. This NK cell subset is poorly cytotoxic against otherwise-NK-cell-susceptible and antibody-opsonized targets. Accordingly, NK cell depletion does not significantly alter KSHV infection in humanized mice. These data suggest that KSHV might escape NK-cell-mediated immune control by driving CD56(-)CD16(+) NK cell differentiation.

Keywords

CD56-negative NK cells, EBV, Epstein-Barr virus, KSHV, Kaposi sarcoma-associated herpesvirus, humanized mouse model, natural killer cells

Rights and Permissions

Copyright 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI of Published Version

10.1016/j.celrep.2021.109056

Source

Caduff N, McHugh D, Rieble L, Forconi CS, Ong'echa JM, Oluoch PO, Raykova A, Murer A, Böni M, Zuppiger L, Schulz TF, Blackbourn DJ, Chijioke O, Moormann AM, Münz C. KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection. Cell Rep. 2021 May 4;35(5):109056. doi: 10.1016/j.celrep.2021.109056. PMID: 33951431. Link to article on publisher's site

Journal/Book/Conference Title

Cell reports

Related Resources

Link to Article in PubMed

PubMed ID

33951431

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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