UMMS Affiliation

Department of Medicine, Division of Infectious Diseases And Immunology

Publication Date

2021-05-03

Document Type

Article

Disciplines

Biochemistry | Medicinal and Pharmaceutical Chemistry | Medicinal-Pharmaceutical Chemistry | Nucleic Acids, Nucleotides, and Nucleosides | Therapeutics

Abstract

Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.

Keywords

antisense, medicinal chemistry, oligonucleotide, structure activity relationship, therapeutic

Rights and Permissions

Copyright © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

DOI of Published Version

10.3390/biomedicines9050503

Source

Agrawal S. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey. Biomedicines. 2021 May 3;9(5):503. doi: 10.3390/biomedicines9050503. PMID: 34063675; PMCID: PMC8147625. Link to article on publisher's site

Journal/Book/Conference Title

Biomedicines

Related Resources

Link to Article in PubMed

PubMed ID

34063675

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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