UMMS Affiliation
Department of Medicine, Division of Infectious Diseases And Immunology
Publication Date
2021-05-03
Document Type
Article
Disciplines
Biochemistry | Medicinal and Pharmaceutical Chemistry | Medicinal-Pharmaceutical Chemistry | Nucleic Acids, Nucleotides, and Nucleosides | Therapeutics
Abstract
Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.
Keywords
antisense, medicinal chemistry, oligonucleotide, structure activity relationship, therapeutic
Rights and Permissions
Copyright © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
10.3390/biomedicines9050503
Source
Agrawal S. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey. Biomedicines. 2021 May 3;9(5):503. doi: 10.3390/biomedicines9050503. PMID: 34063675; PMCID: PMC8147625. Link to article on publisher's site
Journal/Book/Conference Title
Biomedicines
Related Resources
PubMed ID
34063675
Repository Citation
Agrawal S. (2021). The Evolution of Antisense Oligonucleotide Chemistry - A Personal Journey. Open Access Publications by UMMS Authors. https://doi.org/10.3390/biomedicines9050503. Retrieved from https://escholarship.umassmed.edu/oapubs/4714
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Biochemistry Commons, Medicinal and Pharmaceutical Chemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Therapeutics Commons