Department of Medicine, Division of Infectious Diseases And Immunology
Biochemistry | Medicinal and Pharmaceutical Chemistry | Medicinal-Pharmaceutical Chemistry | Nucleic Acids, Nucleotides, and Nucleosides | Therapeutics
Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.
antisense, medicinal chemistry, oligonucleotide, structure activity relationship, therapeutic
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DOI of Published Version
Agrawal S. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey. Biomedicines. 2021 May 3;9(5):503. doi: 10.3390/biomedicines9050503. PMID: 34063675; PMCID: PMC8147625. Link to article on publisher's site
Agrawal S. (2021). The Evolution of Antisense Oligonucleotide Chemistry - A Personal Journey. Open Access Publications by UMass Chan Authors. https://doi.org/10.3390/biomedicines9050503. Retrieved from https://escholarship.umassmed.edu/oapubs/4714
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