UMMS Affiliation
MassBiologics
Publication Date
2021-03-01
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Immunology and Infectious Disease | Infectious Disease | Microbiology | Virus Diseases
Abstract
Molecular determinants of SARS-CoV-2 replication fitness and sensitivity to neutralization via the humoral immune response critically inform efforts to combat the COVID-19 pandemic. Work published recently by Plante et al. in Nature highlights a key role for the D614G variant of the viral spike glycoprotein (S protein) in these processes.
Keywords
SARS-CoV-2, replication, COVID-19
Rights and Permissions
Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/s41392-021-00498-3
Source
Engelman KD, Engelman AN. D614G and SARS-CoV-2 replication fitness. Signal Transduct Target Ther. 2021 Mar 1;6(1):99. doi: 10.1038/s41392-021-00498-3. PMID: 33649290; PMCID: PMC7919242. Link to article on publisher's site
Journal/Book/Conference Title
Signal transduction and targeted therapy
Related Resources
PubMed ID
33649290
Repository Citation
Engelman KD, Engelman AN. (2021). D614G and SARS-CoV-2 replication fitness. Open Access Publications by UMMS Authors. https://doi.org/10.1038/s41392-021-00498-3. Retrieved from https://escholarship.umassmed.edu/oapubs/4664
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Immunology and Infectious Disease Commons, Infectious Disease Commons, Microbiology Commons, Virus Diseases Commons