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Amino Acids, Peptides, and Proteins | Immunology and Infectious Disease | Infectious Disease | Microbiology | Virus Diseases


Molecular determinants of SARS-CoV-2 replication fitness and sensitivity to neutralization via the humoral immune response critically inform efforts to combat the COVID-19 pandemic. Work published recently by Plante et al. in Nature highlights a key role for the D614G variant of the viral spike glycoprotein (S protein) in these processes.


SARS-CoV-2, replication, COVID-19

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Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

DOI of Published Version



Engelman KD, Engelman AN. D614G and SARS-CoV-2 replication fitness. Signal Transduct Target Ther. 2021 Mar 1;6(1):99. doi: 10.1038/s41392-021-00498-3. PMID: 33649290; PMCID: PMC7919242. Link to article on publisher's site

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Signal transduction and targeted therapy

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.