UMMS Affiliation
Department of Medicine, Division of Rheumatology
Publication Date
2021-01-20
Document Type
Article
Disciplines
Biomaterials | Cell Biology | Molecular, Cellular, and Tissue Engineering | Musculoskeletal System
Abstract
Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterial-demineralized bone paper-directs osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype. These cells activate and shift their secretory profile to induce osteoclastogenesis in response to chemical stimulation. Quantitative spatial mapping of cellular activities in resting and activated bone surface coculture showed that the resting-state bone lining cell network actively directs localized bone remodeling by means of paracrine signaling and cell-to-cell contact. This model may facilitate further investigation of trabecular bone niche biology.
Keywords
trabecular bone, bone remodeling
Rights and Permissions
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
DOI of Published Version
10.1126/sciadv.abd6495
Source
Park Y, Cheong E, Kwak JG, Carpenter R, Shim JH, Lee J. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv. 2021 Jan 20;7(4):eabd6495. doi: 10.1126/sciadv.abd6495. PMID: 33523925; PMCID: PMC7817107. Link to article on publisher's site
Journal/Book/Conference Title
Science advances
Related Resources
PubMed ID
33523925
Repository Citation
Park Y, Cheong E, Kwak J, Carpenter R, Shim J, Lee J. (2021). Trabecular bone organoid model for studying the regulation of localized bone remodeling. Open Access Publications by UMMS Authors. https://doi.org/10.1126/sciadv.abd6495. Retrieved from https://escholarship.umassmed.edu/oapubs/4569
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Included in
Biomaterials Commons, Cell Biology Commons, Molecular, Cellular, and Tissue Engineering Commons, Musculoskeletal System Commons