Department of Microbiology and Physiological Systems
Immunity | Immunology of Infectious Disease | Virology
BACKGROUND: In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the immune system.
MAIN BODY: Herpesviridae family members trigger TLRs to elicit cytokines in the process of infection to activate antiviral innate immune responses in host cells. This review aims to clarify the role of TLRs in the innate immunity defense against herpesviridae, and systematically describes the processes of TLR actions and herpesviridae recognition as well as the signal transduction pathways involved.
CONCLUSIONS: Future studies of the interactions between TLRs and herpesviridae infections, especially the subsequent signaling pathways, will not only contribute to the planning of effective antiviral therapies but also provide new molecular targets for the development of antiviral drugs.
Herpesviridae, Immune mechanism, Toll-like receptor, Viral infection
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DOI of Published Version
Zheng W, Xu Q, Zhang Y, E X, Gao W, Zhang M, Zhai W, Rajkumar RS, Liu Z. Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways. Virol J. 2020 Dec 9;17(1):192. doi: 10.1186/s12985-020-01463-2. Erratum in: Virol J. 2020 Dec 31;17(1):199. PMID: 33298111; PMCID: PMC7726878. Link to article on publisher's site
Zheng W, Xu Q, Zhang Y, E X, Gao W, Zhang M, Zhai W, Rajkumar RS, Liu Z. (2020). Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways. Open Access Publications by UMMS Authors. https://doi.org/10.1186/s12985-020-01463-2. Retrieved from https://escholarship.umassmed.edu/oapubs/4526
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This work is licensed under a Creative Commons Attribution 4.0 License.