UMMS Affiliation

Department of Surgery

Publication Date


Document Type



Analytical, Diagnostic and Therapeutic Techniques and Equipment | Biomedical Devices and Instrumentation | Biotechnology | Chemistry | Molecular, Cellular, and Tissue Engineering | Surgery


Modern day biomedical applications require progressions that combine advanced technology with the conformability of naturally occurring, complex biosystems. These advancements yield conformational interactions between the biomedical devices and the biological organisms' structures. Biomedical applications that adapt origami-inspired approaches have accrued aspired advances. Along with application-specific advantages, the most pertinent advances provided by origami-inspired strategies include voluminous structures with the ability to conform to biosystems, shape-shifting from two-dimensional (2D) to three-dimensional (3D) structures, and biocompatibility. Throughout this paper, the exploration of new studies, primarily within the past decade, with origami-based applications of biomedical devices, including their theories, experimental results, and plans for future testing are reviewed. This mini-review contains examples that aid the advancement of biomedical applications and hold promising future discoveries. The origami-inspired applications discussed within this paper are tissue scaffolds, drug delivery approaches, stents and catheters, implants, microfluidic devices, biosensors, and origami usage in surgery.


Implants, Layers, Scaffolds, Chemical structure, Microfluidic devices

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Copyright © 2020 The Authors. Published by American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.

DOI of Published Version



Ahmed AR, Gauntlett OC, Camci-Unal G. Origami-Inspired Approaches for Biomedical Applications. ACS Omega. 2020 Dec 27;6(1):46-54. doi: 10.1021/acsomega.0c05275. PMID: 33458458; PMCID: PMC7807481. Link to article on publisher's site

Journal/Book/Conference Title

ACS omega

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PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.