UMMS Affiliation
Department of Medicine, Division of Rheumatology
Publication Date
2020-11-15
Document Type
Article Postprint
Disciplines
Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases
Abstract
OBJECTIVE: Therapeutic response was evaluated among new apremilast, methotrexate, or biologic disease-modifying anti-rheumatic drug (bDMARD) initiators with oligoarticular psoriatic arthritis (PsA).
METHODS: Patients with oligoarticular PsA in the Corrona PsA/Spondyloarthritis Registry initiating treatment with apremilast, methotrexate, or bDMARD and completing 6-month follow-up were included.
RESULTS: In total, 150 patients initiated monotherapy (apremilast: n=34; methotrexate: n=15; bDMARD: n=101). Apremilast initiators had higher baseline disease activity than methotrexate initiators. At follow-up, apremilast initiators experienced numerically greater disease activity improvements than methotrexate initiators and similar improvements to bDMARD initiators.
CONCLUSION: Findings suggest apremilast monotherapy is an effective option for patients with oligoarticular PsA.
Keywords
arthritis, psoriatic arthritis, TNF receptors, methotrexate
Rights and Permissions
© 2020 The Journal of Rheumatology. This is a pre-copyediting, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version is available online at https://doi.org/10.3899/jrheum.191209. Accepted Manuscript posted with a 12-month embargo as allowed by publisher.
DOI of Published Version
10.3899/jrheum.191209
Source
Ogdie A, Liu M, Glynn M, Emeanuru K, Harrold L, Richter S, Guerette B, Mease PJ. Descriptive Comparisons of the Impact of Apremilast and Methotrexate Monotherapy in Oligoarticular Psoriatic Arthritis: the Corrona Psoriatic Arthritis/Spondyloarthritis Registry Results. J Rheumatol. 2020 Nov 15:jrheum.191209. doi: 10.3899/jrheum.191209. Epub ahead of print. PMID: 33191289. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of rheumatology
Related Resources
PubMed ID
33191289
Repository Citation
Ogdie A, Liu M, Glynn M, Emeanuru K, Harrold LR, Richter S, Guerette B, Mease PJ. (2020). Descriptive Comparisons of the Impact of Apremilast and Methotrexate Monotherapy in Oligoarticular Psoriatic Arthritis: the Corrona Psoriatic Arthritis/Spondyloarthritis Registry Results. Open Access Publications by UMMS Authors. https://doi.org/10.3899/jrheum.191209. Retrieved from https://escholarship.umassmed.edu/oapubs/4468
Included in
Musculoskeletal Diseases Commons, Rheumatology Commons, Skin and Connective Tissue Diseases Commons