UMMS Affiliation

Department of Radiology

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Document Type



Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Radiology


Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very successful application in small animal imaging, there has been a resurgence of the use of MPH collimators for clinical cardiac and brain studies, as well as other small field-of-view applications. This article reviews the basic principles of MPH collimators and introduces currently available and proposed clinical MPH SPECT systems.


Single photon emission computed tomography (SPECT), brain, cardiac, collimator, multi-pinhole

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Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:

DOI of Published Version



Ozsahin I, Chen L, Könik A, King MA, Beekman FJ, Mok GSP. The clinical utilities of multi-pinhole single photon emission computed tomography. Quant Imaging Med Surg. 2020 Oct;10(10):2006-2029. doi: 10.21037/qims-19-1036. PMID: 33014732; PMCID: PMC7495312. Link to article on publisher's site

Journal/Book/Conference Title

Quantitative imaging in medicine and surgery

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Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.