Department of Population and Quantitative Health Sciences
Letter to the Editor
Digestive System Diseases | Gastroenterology | Research Methods in Life Sciences | Therapeutics
Dear Editor, In their network meta-analyses (NMAs) of treatments for ulcerative colitis (UC), Singh et al1 did not take into account a complication associated with studies that re-randomized patients for the maintenance phase: differential carryover effects from induction can bias the results. In those studies, patients who responded to induction were re-randomized to maintenance treatments that included placebo. If, however, carryover effects from induction differ substantially among active treatments, the effects of those treatments, relative to placebo, are not comparable.
Ulcerative Colitis, treatment, network meta-analyses, pharmacotherapies
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© 2020 by the AGA Institute. This article is available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
DOI of Published Version
Naessens D, Cameron C, Hoaglin DC. Network Meta-Analysis of Ulcerative Colitis Pharmacotherapies: Carryover Effects from Induction and Bias of the Results. Clin Gastroenterol Hepatol. 2020 Oct 13:S1542-3565(20)31428-2. doi: 10.1016/j.cgh.2020.10.016. Epub ahead of print. PMID: 33065309. Link to article on publisher's site
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Naessens D, Cameron C, Hoaglin DC. (2020). Network Meta-Analysis of Ulcerative Colitis Pharmacotherapies: Carryover Effects from Induction and Bias of the Results. Open Access Publications by UMMS Authors. https://doi.org/10.1016/j.cgh.2020.10.016. Retrieved from https://escholarship.umassmed.edu/oapubs/4398
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.