Program in Bioinformatics and Integrative Biology; Garber Lab; Program in Molecular Medicine
Biodiversity | Computational Biology | Ecology and Evolutionary Biology | Genomics
The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
Comparative genomics, Ecological genetics, Evolutionary genetics, Genome informatics, Phylogenetics
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DOI of Published Version
Zoonomia Consortium. A comparative genomics multitool for scientific discovery and conservation. Nature. 2020 Nov;587(7833):240-245. doi: 10.1038/s41586-020-2876-6. Epub 2020 Nov 11. PMID: 33177664. View article on publisher's site
Zoonomia Consortium, Genereux DP, Garber M, Lindblad-Toh K, Karlsson EK. (2020). A comparative genomics multitool for scientific discovery and conservation. Open Access Publications by UMMS Authors. https://doi.org/10.1038/s41586-020-2876-6. Retrieved from https://escholarship.umassmed.edu/oapubs/4380
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.