Department of Psychiatry
Animal Sciences | Genetics and Genomics
Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.
Genome, Genomics, Genotype, Mutation, Sequencing
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DOI of Published Version
Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Sci Rep. 2020 Sep 28;10(1):15876. doi: 10.1038/s41598-020-72239-5. PMID: 32985525; PMCID: PMC7522971. Link to article on publisher's site
Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. (2020). Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Open Access Articles. https://doi.org/10.1038/s41598-020-72239-5. Retrieved from https://escholarship.umassmed.edu/oapubs/4377
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This work is licensed under a Creative Commons Attribution 4.0 License.