UMMS Affiliation
Department of Psychiatry
Publication Date
2020-09-28
Document Type
Article
Disciplines
Animal Sciences | Genetics and Genomics
Abstract
Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.
Keywords
Genome, Genomics, Genotype, Mutation, Sequencing
Rights and Permissions
Copyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/s41598-020-72239-5
Source
Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Sci Rep. 2020 Sep 28;10(1):15876. doi: 10.1038/s41598-020-72239-5. PMID: 32985525; PMCID: PMC7522971. Link to article on publisher's site
Journal/Book/Conference Title
Scientific reports
Related Resources
PubMed ID
32985525
Repository Citation
Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV, Rogaev EI. (2020). Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Open Access Articles. https://doi.org/10.1038/s41598-020-72239-5. Retrieved from https://escholarship.umassmed.edu/oapubs/4377
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.