Division of Rheumatology, Department of Medicine; Li Weibo Institute for Rare Diseases Research
Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Cellular and Molecular Physiology | Orthopedics | Rheumatology
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts.
bone, bone remodeling, osteoblast, osteoclast
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DOI of Published Version
Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020 Sep 10;9(9):E2073. doi: 10.3390/cells9092073. PMID: 32927921. Link to article on publisher's site
Kim J, Lin C, Stavre Z, Greenblatt MB, Shim J. (2020). Osteoblast-Osteoclast Communication and Bone Homeostasis. Open Access Articles. https://doi.org/10.3390/cells9092073. Retrieved from https://escholarship.umassmed.edu/oapubs/4353
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This work is licensed under a Creative Commons Attribution 4.0 License.