UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date


Document Type



Digestive System Diseases | Hemic and Immune Systems | Immunology and Infectious Disease


Macrophages constitute a key component of our immune system and play an important role in immune surveillance. Hepatic macrophages are a heterogeneous population of immune cells that mainly comprises of embryonically-derived resident Kupffer cells (KCs), and circulating monocyte-derived macrophages (MoMFs). They play a critical role in disease initiation and progression as well as contribute to disease resolution. Traditionally, macrophages were defined by two broad subsets: classically-activated pro-inflammatory M1 or alternatively-activated anti-inflammatory M2 macrophages. However, it has been recognized that macrophages can differentiate into multiple phenotypes with distinct functions based on the tissue microenvironment.


liver diseases, macrophage phenotypes, therapeutic targets, treatment strategies, innate immunity

Rights and Permissions

Copyright © 2020 Bansal, Mandrekar, Mohanty and Weiskirchen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI of Published Version



Bansal R, Mandrekar P, Mohanty SK, Weiskirchen R. Editorial: Macrophages in Liver Disease. Front Immunol. 2020 Aug 4;11:1754. doi: 10.3389/fimmu.2020.01754. PMID: 32849626; PMCID: PMC7417358. Link to article on publisher's site

Journal/Book/Conference Title

Frontiers in immunology

Related Resources

Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.