UMMS Affiliation

Department of Dermatology; Department of Pathology; Department of Medicine; Graduate School of Biomedical Sciences

Publication Date

2020-07-02

Document Type

Article

Disciplines

Dermatology | Hemic and Immune Systems | Immune System Diseases | Immunopathology | Pathology | Skin and Connective Tissue Diseases

Abstract

Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.

Keywords

CLE, UV light, autoantibodies, autoimmune, cutaneous, interface dermatitis, lupus, lupus band

Rights and Permissions

Copyright © 2020 Garelli, Refat, Nanaware, Ramirez-Ortiz, Rashighi and Richmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI of Published Version

10.3389/fimmu.2020.01353

Source

Garelli CJ, Refat MA, Nanaware PP, Ramirez-Ortiz ZG, Rashighi M, Richmond JM. Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis. Front Immunol. 2020 Jul 2;11:1353. doi: 10.3389/fimmu.2020.01353. PMID: 32714331; PMCID: PMC7343764. Link to article on publisher's site

Journal/Book/Conference Title

Frontiers in immunology

Related Resources

Link to Article in PubMed

PubMed ID

32714331

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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