Title
Defining trained immunity and its role in health and disease
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Publication Date
2020-06-01
Document Type
Article
Disciplines
Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Immunopathology
Abstract
Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
Keywords
Immunotherapy, Infection, Vaccines
DOI of Published Version
10.1038/s41577-020-0285-6
Source
Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. PMID: 32132681; PMCID: PMC7186935. Link to article on publisher's site
Journal/Book/Conference Title
Nature reviews. Immunology
Related Resources
PubMed ID
32132681
Repository Citation
Netea MG, Latz E. (2020). Defining trained immunity and its role in health and disease. Open Access Publications by UMMS Authors. https://doi.org/10.1038/s41577-020-0285-6. Retrieved from https://escholarship.umassmed.edu/oapubs/4276
Comments
Full author list omitted for brevity. For the full list of authors, see article.