UMMS Affiliation

Program in Molecular Medicine; Department of Molecular, Cell, and Cancer Biology; Graduate School of Biomedical Sciences

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Animal Experimentation and Research | Cancer Biology | Disease Modeling | Genetics and Genomics | Molecular Biology | Neoplasms


Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.


Melanoma, genetics, melanocytes, microenvironment, modeling, xenografts, zebrafish

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

DOI of Published Version



Frantz WT, Ceol CJ. From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells. 2020 May 22;9(5):E1289. doi: 10.3390/cells9051289. PMID: 32455885. Link to article on publisher's site

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.