UMMS Affiliation

School of Medicine; Department of Medicine

Publication Date


Document Type



Dermatology | Hematology | Hemic and Lymphatic Diseases | Neoplasms | Oncology | Skin and Connective Tissue Diseases


Cutaneous B-cell lymphomas (CBCL) are rare heterogeneous neoplastic diseases composing about 22.5% of all cutaneous lymphomas. These diseases can be divided into primary and secondary cutaneous variants with primary cutaneous B-cell lymphoma (PCBCL) divided into three distinct entities including primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). Secondary cutaneous diffuse large B-cell lymphoma (CDLBCL) and PCDLBCL, LT are more aggressive neoplasms compared to the aforementioned CBCL with survival rates of 37% and 50% after 5 years, respectively. CDLBCL can present as cutaneous or subcutaneous nodules, papular lesions, or indurated plaques. Here, we present a case of CDLBCL of an 88-year-old female that was mistaken for lower extremity cellulitis with phlegmon. Our patient failed two courses of antibiotic therapy as an outpatient and received a third as an inpatient before a cutaneous biopsy clinched the diagnosis.


Cutaneous Diffuse Large B-Cell Lymphoma, cutaneous lymphomas

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Copyright © 2020 Mary Awad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Awad M, Holzwanger E, Jubbal S. A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma. Case Rep Dermatol Med. 2020 Apr 7;2020:8310602. doi: 10.1155/2020/8310602. PMID: 32318298; PMCID: PMC7166262. Link to article on publisher's site

Journal/Book/Conference Title

Case reports in dermatological medicine

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PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.