UMMS Affiliation

Horae Gene Therapy Center; Department of Radiology

Publication Date

2020-03-11

Document Type

Article

Disciplines

Animal Experimentation and Research | Investigative Techniques | Musculoskeletal Diseases | Nervous System Diseases | Research Methods in Life Sciences | Translational Medical Research | Veterinary Medicine

Abstract

Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often recapitulate the human disease state. In particular, numerous models have been discovered in dogs and have a fundamental role in bridging proof of concept studies in mice to human clinical trials. The present article is a review that highlights current canine models of human diseases, including Alzheimer's disease, degenerative myelopathy, neuronal ceroid lipofuscinosis, globoid cell leukodystrophy, Duchenne muscular dystrophy, mucopolysaccharidosis, and fucosidosis. The goal of the review is to discuss canine and human neurodegenerative pathophysiologic similarities, introduce the animal models, and shed light on the ability of canine models to facilitate current and future treatment trials.

Keywords

canine, gene therapy, large animal model, neurodegeneration, translational

Rights and Permissions

Copyright © 2020 Story, Miller, Bradbury, Million, Duan, Taghian, Faissler, Fernau, Beecy and Gray-Edwards. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI of Published Version

10.3389/fvets.2020.00080

Source

Story BD, Miller ME, Bradbury AM, Million ED, Duan D, Taghian T, Faissler D, Fernau D, Beecy SJ, Gray-Edwards HL. Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases. Front Vet Sci. 2020 Mar 11;7:80. doi: 10.3389/fvets.2020.00080. PMID: 32219101; PMCID: PMC7078110. Link to article on publisher's site

Journal/Book/Conference Title

Frontiers in veterinary science

Related Resources

Link to Article in PubMed

PubMed ID

32219101

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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