Department of Molecular, Cell and Cancer Biology
Chemicals and Drugs | Environmental Public Health | Gender and Sexuality | Maternal and Child Health | Reproductive and Urinary Physiology
We assessed the associations of prenatal diethylstilbestrol (DES) exposure, a potent estrogen, with sexual orientation and gender identity in 3306 women and 1848 men who participated in a study of prenatal DES exposure. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models adjusted for birth year, study cohort, and education. Among women, the OR for DES in relation to reporting sexual orientation identity as nonheterosexual was 0.61 (95% CI 0.40-0.92) primarily due to a strong inverse association with a lesbian identity (OR 0.44, 95% CI 0.25-0.76). Among men, the OR for DES in relation to reporting a nonheterosexual sexual orientation identity was 1.4 (95% CI 0.82-2.4), and ORs were similar for having a gay identity (1.4, 95% CI 0.72-2.85) and bisexual identity (1.4, 95% CI 0.57-3.5). Only five individuals reported a gender identity not conforming to that assigned at birth, preventing meaningful analysis. Women who were prenatally exposed to DES were less likely to have a lesbian or bisexual orientation, while DES-exposed men were somewhat more likely to report being gay or bisexual, but estimates were imprecise.
Diethylstilbestrol, Gender identity, In utero exposure, Sexual orientation identity
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DOI of Published Version
Troisi R, Palmer JR, Hatch EE, Strohsnitter WC, Huo D, Hyer M, Fredriksen-Goldsen KI, Hoover R, Titus L. Gender Identity and Sexual Orientation Identity in Women and Men Prenatally Exposed to Diethylstilbestrol. Arch Sex Behav. 2020 Feb;49(2):447-454. doi: 10.1007/s10508-020-01637-7. Epub 2020 Jan 23. PMID: 31975033; PMCID: PMC7031187. Link to article on publisher's site
Archives of sexual behavior
Troisi R, Palmer JR, Hatch EE, Strohsnitter WC, Huo D, Hyer M, Fredriksen-Goldsen KI, Hoover R, Titus L. (2020). Gender Identity and Sexual Orientation Identity in Women and Men Prenatally Exposed to Diethylstilbestrol. Open Access Articles. https://doi.org/10.1007/s10508-020-01637-7. Retrieved from https://escholarship.umassmed.edu/oapubs/4150
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This work is licensed under a Creative Commons Attribution 4.0 License.