Program in Molecular Medicine
Bacterial Infections and Mycoses | Hemic and Immune Systems | Immunology of Infectious Disease | Immunopathology | Immunoprophylaxis and Therapy | Infectious Disease
Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90% of pathogens. In order to provide protection for both serum and mucosal areas, we have tested a combinatorial approach of both parenteral and oral administration of antigens for diseases caused by a viral pathogen, Hepatitis B, and a fungal pathogen, Coccidioides. We demonstrate that co-administration by the parenteral and oral routes is a useful tool to increase the overall immune response. This can include achieving an immune response in tissues that are not elicited when using only one route of administration, providing a higher level of response that can lead to fewer required doses or possibly providing a better response for individuals that are considered poor or non-responders.
bioencapsulation, immunogenicity, maize oral vaccine, mucosal, plant vaccine, subunit vaccine, supercritical fluid extraction
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
Hayden CA, Landrock D, Hung CY, Ostroff G, Fake GM, Walker JH, Kier A, Howard JA. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines (Basel). 2020 Jan 21;8(1):E37. doi: 10.3390/vaccines8010037. PMID: 31973150. Link to article on publisher's site
Hayden CA, Landrock D, Hung CY, Ostroff GR, Fake GM, Walker JH, Kier A, Howard JA. (2020). Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Open Access Articles. https://doi.org/10.3390/vaccines8010037. Retrieved from https://escholarship.umassmed.edu/oapubs/4147
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Bacterial Infections and Mycoses Commons, Hemic and Immune Systems Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, Immunoprophylaxis and Therapy Commons, Infectious Disease Commons