UMMS Affiliation

Program in Molecular Medicine

Publication Date

2020-01-21

Document Type

Article

Disciplines

Bacterial Infections and Mycoses | Hemic and Immune Systems | Immunology of Infectious Disease | Immunopathology | Immunoprophylaxis and Therapy | Infectious Disease

Abstract

Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90% of pathogens. In order to provide protection for both serum and mucosal areas, we have tested a combinatorial approach of both parenteral and oral administration of antigens for diseases caused by a viral pathogen, Hepatitis B, and a fungal pathogen, Coccidioides. We demonstrate that co-administration by the parenteral and oral routes is a useful tool to increase the overall immune response. This can include achieving an immune response in tissues that are not elicited when using only one route of administration, providing a higher level of response that can lead to fewer required doses or possibly providing a better response for individuals that are considered poor or non-responders.

Keywords

bioencapsulation, immunogenicity, maize oral vaccine, mucosal, plant vaccine, subunit vaccine, supercritical fluid extraction

Rights and Permissions

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

DOI of Published Version

10.3390/vaccines8010037

Source

Hayden CA, Landrock D, Hung CY, Ostroff G, Fake GM, Walker JH, Kier A, Howard JA. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines (Basel). 2020 Jan 21;8(1):E37. doi: 10.3390/vaccines8010037. PMID: 31973150. Link to article on publisher's site

Journal/Book/Conference Title

Vaccines

Comments

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Related Resources

Link to Article in PubMed

PubMed ID

31973150

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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