UMMS Affiliation

Department of Pathology; Department of Otolaryngology; Department of Medicine, Division of Hematology Oncology

Publication Date


Document Type



Hematology | Hemic and Lymphatic Diseases | Stomatognathic Diseases | Tissues


Mucous membrane plasmacytosis (MMP) is an uncommon variant of mucositis represented by a polyclonal plasma cell infiltration of mucosal tissue. Various clinical presentations in the upper airway have been reported ranging from erythematous mucosa to fungating masses. Histologic features include mucosal epithelial hyperplasia or psoriasiform changes with a dense submucosal infiltrate of polytypic plasma cells. Molecular studies for immunoglobulin gene rearrangement should be performed in all cases of MMP to rule out clonal neoplastic expansion of plasma cells. We present a case of MMP with over 15 years of clinical follow-up, emphasizing the relatively benign clinical course of this disorder.


Long-term follow-up, Mucous membrane plasmacytosis

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© 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (

DOI of Published Version



Makarenko VV, Vaezi AE, Brettler DB, Hutchinson L, Woda BA, Chen BJ. Laryngeal mucous membrane plasmacytosis with 15 year follow-up: Case report and literature review. Leuk Res Rep. 2019 Nov 27;13:100190. doi: 10.1016/j.lrr.2019.100190. PMID: 31867207; PMCID: PMC6906643. Link to article on publisher's site

Journal/Book/Conference Title

Leukemia research reports

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Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.