Title
Abnormally Low Hemoglobin A1c as Harbinger of Hemoglobinopathy
UMMS Affiliation
Department of Family Medicine and Community Health
Publication Date
2019-11-08
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Biochemical Phenomena, Metabolism, and Nutrition | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Diagnosis | Endocrine System Diseases | Family Medicine | Hematology | Hemic and Lymphatic Diseases | Nutritional and Metabolic Diseases | Primary Care
Abstract
Hemoglobin A1c is frequently used in primary care to screen for and monitor disorders of glucose metabolism. A number of clinical syndromes may impact the accuracy of this laboratory value. This report describes a case of abnormally low hemoglobin A1c that was the result of an asymptomatic compound hemoglobinopathy (homozygous hemoglobin S disease and hereditary persistence of fetal hemoglobin) that had gone previously undiagnosed. Primary care physicians must be aware of such pitfalls in the use of this laboratory value and be prepared to use other values to monitor for and assess disorders of glucose metabolism.
Keywords
Diabetes Mellitus, Fetal Hemoglobin, Glucose, Glycated Hemoglobin A, Hematology, Hemoglobinopathies, Primary Care Physicians, Primary Health Care
DOI of Published Version
10.3122/jabfm.2019.06.190124
Source
J Am Board Fam Med. 2019 Nov-Dec;32(6):923-924. doi: 10.3122/jabfm.2019.06.190124. Link to article on publisher's site
Journal/Book/Conference Title
Journal of the American Board of Family Medicine : JABFM
Related Resources
PubMed ID
31704761
Repository Citation
St. Louis J, Valdini A. (2019). Abnormally Low Hemoglobin A1c as Harbinger of Hemoglobinopathy. Open Access Publications by UMass Chan Authors. https://doi.org/10.3122/jabfm.2019.06.190124. Retrieved from https://escholarship.umassmed.edu/oapubs/4060