Title

Abnormally Low Hemoglobin A1c as Harbinger of Hemoglobinopathy

UMMS Affiliation

Department of Family Medicine and Community Health

Publication Date

2019-11-08

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Biochemical Phenomena, Metabolism, and Nutrition | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Diagnosis | Endocrine System Diseases | Family Medicine | Hematology | Hemic and Lymphatic Diseases | Nutritional and Metabolic Diseases | Primary Care

Abstract

Hemoglobin A1c is frequently used in primary care to screen for and monitor disorders of glucose metabolism. A number of clinical syndromes may impact the accuracy of this laboratory value. This report describes a case of abnormally low hemoglobin A1c that was the result of an asymptomatic compound hemoglobinopathy (homozygous hemoglobin S disease and hereditary persistence of fetal hemoglobin) that had gone previously undiagnosed. Primary care physicians must be aware of such pitfalls in the use of this laboratory value and be prepared to use other values to monitor for and assess disorders of glucose metabolism.

Keywords

Diabetes Mellitus, Fetal Hemoglobin, Glucose, Glycated Hemoglobin A, Hematology, Hemoglobinopathies, Primary Care Physicians, Primary Health Care

DOI of Published Version

10.3122/jabfm.2019.06.190124

Source

J Am Board Fam Med. 2019 Nov-Dec;32(6):923-924. doi: 10.3122/jabfm.2019.06.190124. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Board of Family Medicine : JABFM

Related Resources

Link to Article in PubMed

PubMed ID

31704761

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