Program in Molecular Medicine; Department of Medicine, Division of Infectious Diseases and Immunology
Bacterial Infections and Mycoses | Bacteriology | Immunity | Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Pathogenic Microbiology | Preventive Medicine | Therapeutics
Vaccines are considered the bedrock of preventive medicine. However, for many pathogens, it has been challenging to develop vaccines that stimulate protective, long-lasting immunity. We have developed a novel approach using beta-1,3-D-glucans (BGs), natural polysaccharides abundantly present in fungal cell walls, as a biomaterial platform for vaccine delivery. BGs simultaneously provide for receptor-targeted antigen delivery to specialized antigen-presenting cells together with adjuvant properties to stimulate antigen-specific and trained non-specific immune responses. This review focuses on various approaches of using BG particles (GPs) to develop bacterial and fungal vaccine candidates. A special case history for the development of an effective GP tularaemia vaccine candidate is highlighted.
beta-glucans, fungal, tularemia, vaccine
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© 2019 Crown copyright. Clinical and Experimental Immunology © 2019 British Society for Immunology. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
DOI of Published Version
Clin Exp Immunol. 2019 Nov;198(2):143-152. doi: 10.1111/cei.13356. Epub 2019 Sep 12. Link to article on publisher's site
Clinical and experimental immunology
Abraham A, Ostroff GR, Levitz SM, Oyston PC. (2019). A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens. Open Access Publications by UMMS Authors. https://doi.org/10.1111/cei.13356. Retrieved from https://escholarship.umassmed.edu/oapubs/4054
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Bacterial Infections and Mycoses Commons, Bacteriology Commons, Immunity Commons, Immunology of Infectious Disease Commons, Immunoprophylaxis and Therapy Commons, Pathogenic Microbiology Commons, Preventive Medicine Commons, Therapeutics Commons