UMMS Affiliation

Program in Molecular Medicine; Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

2019-11-01

Document Type

Article

Disciplines

Bacterial Infections and Mycoses | Bacteriology | Immunity | Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Pathogenic Microbiology | Preventive Medicine | Therapeutics

Abstract

Vaccines are considered the bedrock of preventive medicine. However, for many pathogens, it has been challenging to develop vaccines that stimulate protective, long-lasting immunity. We have developed a novel approach using beta-1,3-D-glucans (BGs), natural polysaccharides abundantly present in fungal cell walls, as a biomaterial platform for vaccine delivery. BGs simultaneously provide for receptor-targeted antigen delivery to specialized antigen-presenting cells together with adjuvant properties to stimulate antigen-specific and trained non-specific immune responses. This review focuses on various approaches of using BG particles (GPs) to develop bacterial and fungal vaccine candidates. A special case history for the development of an effective GP tularaemia vaccine candidate is highlighted.

Keywords

beta-glucans, fungal, tularemia, vaccine

Rights and Permissions

© 2019 Crown copyright. Clinical and Experimental Immunology © 2019 British Society for Immunology. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

DOI of Published Version

10.1111/cei.13356

Source

Clin Exp Immunol. 2019 Nov;198(2):143-152. doi: 10.1111/cei.13356. Epub 2019 Sep 12. Link to article on publisher's site

Journal/Book/Conference Title

Clinical and experimental immunology

Related Resources

Link to Article in PubMed

PubMed ID

31400225

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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