UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

2019-10-08

Document Type

Article Postprint

Disciplines

Amino Acids, Peptides, and Proteins | Biochemistry | Biological Phenomena, Cell Phenomena, and Immunity | Cell Biology | Cells | Genetic Phenomena

Abstract

To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, differentiation as well as the processes of tissue regeneration and wound repair (1). Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states such as fibrosis, muscle diseases, and cancer (2). Mechanotransduction involves the sensing and translation of mechanical forces into biochemical signals, like activation of specific genes and signaling cascades that enable cells to adapt to their physical environment. The signaling pathways involved in mechanical signaling are highly complex, but numerous studies have highlighted a central role for the Hippo pathway and other signaling networks in regulating the YAP and TAZ (YAP/TAZ) proteins to mediate the effects of mechanical stimuli on cellular behavior. How mechanical cues control YAP/TAZ has been poorly understood. However, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pathways for controlling YAP/TAZ. In this review we will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton, and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.

Keywords

Hippo pathway, LATS (Warts, Wts), TAZ, actin, adherens junction, cell signaling, focal adhesions, mechanotransduction, yes-associated protein (YAP)

Rights and Permissions

This research was originally published in the Journal of Biological Chemistry. Ishani Dasgupta and Dannel McCollum, Control of cellular responses to mechanical cues through YAP/TAZ regulation. J. Biol. Chem. 2019. doi:10.1074/jbc.REV119.007963. © the Author(s). Accepted manuscript posted as allowed by publisher's copyright policy at http://www.jbc.org/site/misc/edpolicy.xhtml#copyright.

DOI of Published Version

10.1074/jbc.REV119.007963

Source

J Biol Chem. 2019 Oct 8. pii: jbc.REV119.007963. doi: 10.1074/jbc.REV119.007963. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title

The Journal of biological chemistry

Related Resources

Link to Article in PubMed

PubMed ID

31594864

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