Title
Side effects with inhaled corticosteroids: the physician's perception
UMMS Affiliation
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care
Publication Date
2006-07-15
Document Type
Article
Subjects
Administration, Inhalation; Adult; Asthma; Attitude of Health Personnel; Child; Glucocorticoids; Humans; Metered Dose Inhalers
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The National Asthma Education and Prevention Program 1997 guidelines and 2002 update provide an overview of potential local and systemic side effects associated with inhaled corticosteroids (ICS) and suggest ways of minimizing the risk of these side effects occurring. Despite the guidelines and extensive clinical experience of the safe use of ICS, a significant number of physicians retain concerns regarding side effects. Local side effects may lead to patients discontinuing therapy, with or without the knowledge of their physicians. In particular, concerns regarding systemic side effects, such as growth retardation in children and osteoporosis, remain relatively widespread. Pharmacokinetic studies reveal that different ICS compounds and formulations result in different degrees of systemic bioavailability, indicating possible differences in their potential to cause systemic side effects. However, clinical studies that can be used to differentiate between ICS formulations are generally lacking. Consequently, there is a need to continue to further our understanding of side effects with ICS, with the aim of identifying formulations, devices, and doses with an optimal risk/benefit ratio. The introduction of new agents with potentially improved safety profiles may reassure physicians and patients as to the relative benefits of ICS therapy in asthma.
DOI of Published Version
10.1378/chest.130.1_suppl.41S
Source
Chest. 2006 Jul;130(1 Suppl):41S-53S. Link to article on publisher's site
Journal/Book/Conference Title
Chest
Related Resources
PubMed ID
16840367
Repository Citation
Irwin, Richard S. and Richardson, Naomi D., "Side effects with inhaled corticosteroids: the physician's perception" (2006). Open Access Articles. 401.
https://escholarship.umassmed.edu/oapubs/401