Title
Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Publication Date
2019-10-09
Document Type
Article
Disciplines
Bacterial Infections and Mycoses | Digestive System Diseases | Gastroenterology | Hepatology | Pathological Conditions, Signs and Symptoms
Abstract
Acute‐on‐chronic liver failure (ACLF) can develop in patients with cirrhosis both at the compensated and decompensated stages of liver disease (Fig. 1). The clinical symptoms of ACLF include acute liver decompensation, organ failure (or multiorgan failure), and increased short‐term mortality.1 The triggers for ACLF could be different events including infections, gastrointestinal bleeding, alcohol binge, large‐volume paracentesis, transjugular intrahepatic portosystemic shunt, and surgery, although the precipitating factor cannot be identified in some cases of ACLF.2 Most studies found infection as the most frequent cause of ACLF. The CANONIC study reported bacterial infection in 32.6% of 303 cases, whereas Shi et al. found 27.9% of 404 cases of ACLS linked to bacterial infection.3, 11 In the latter study from Asia, hepatitis B virus exacerbation caused ACLD in 35.8% of reported ACLS cases.3
DOI of Published Version
10.1002/cld.826
Source
Clin Liver Dis (Hoboken). 2019 Oct 9;14(3):103-106. doi: 10.1002/cld.826. eCollection 2019 Sep. Link to article on publisher's site
Journal/Book/Conference Title
Clinical liver disease
Related Resources
PubMed ID
31632659
Repository Citation
Szabo G. (2019). Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection. Open Access Publications by UMass Chan Authors. https://doi.org/10.1002/cld.826. Retrieved from https://escholarship.umassmed.edu/oapubs/4008