Department of Medicine, Division of Cardiovascular Medicine
Cardiology | Cardiovascular Diseases | Fluids and Secretions | Genetic Phenomena | Nervous System | Nervous System Diseases | Nucleic Acids, Nucleotides, and Nucleosides
Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.
MicroRNAs, Stroke, Gene expression, Blood, Hemorrhagic stroke, Cardiovascular diseases, Ischemic stroke, Cerebrovascular diseases
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Copyright: © 2019 Salinas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
PLoS One. 2019 Aug 8;14(8):e0219261. doi: 10.1371/journal.pone.0219261. eCollection 2019. Link to article on publisher's site
Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. (2019). Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. Open Access Articles. https://doi.org/10.1371/journal.pone.0219261. Retrieved from https://escholarship.umassmed.edu/oapubs/3963
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This work is licensed under a Creative Commons Attribution 4.0 License.
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