Mitochondrial dynamics of survivin and "four dimensional" control of tumor cell apoptosis

UMMS Affiliation

Department of Cancer Biology and the Cancer Center

Publication Date


Document Type



Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Mitochondria; Mitosis; Neoplasm Proteins; Neoplasms; Protein Transport; Signal Transduction


Life Sciences | Medicine and Health Sciences


The intense investigation of cell death pathways over the past few years has uncovered elevated complexity with panoply of molecular interactions, multiple intersecting gene networks and bidirectional crosstalk among disparate cellular regulators. What has remained more elusive is how these interactions are spatially arranged in the "four dimensions" of the cell as a whole, and their true relevance to human diseases. Fresh evidence obtained with survivin has unraveled a process of dynamic subcellular shuttling that is required to inhibit apoptosis during tumor growth, with the mitochondrion playing a central, orchestrating role.

DOI of Published Version



Cell Cycle. 2005 Jan;4(1):21-3. Epub 2005 Jan 12.

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

Related Resources

Link to article in PubMed

PubMed ID