Department of Biochemistry and Molecular Pharmacology
Amino Acids, Peptides, and Proteins | Cancer Biology | Cell Biology | Enzymes and Coenzymes | Molecular Biology
Epithelial-mesenchymal transition (EMT) is a reversible cellular process, characterized by changes in gene expression and activation of proteins, favoring the trans-differentiation of the epithelial phenotype to a mesenchymal phenotype. This process increases cell migration and invasion of tumor cells, progression of the cell cycle, and resistance to apoptosis and chemotherapy, all of which support tumor progression. One of the signaling pathways involved in tumor progression is the MAPK pathway. Within this family, the ERK subfamily of proteins is known for its contributions to EMT. The ERK subfamily is divided into typical (ERK 1/2/5), and atypical (ERK 3/4/7/8) members. These kinases are overexpressed and hyperactive in various types of cancer. They regulate diverse cellular processes such as proliferation, migration, metastasis, resistance to chemotherapy, and EMT. In this context, in vitro and in vivo assays, as well as studies in human patients, have shown that ERK favors the expression, function, and subcellular relocalization of various proteins that regulate EMT, thus promoting tumor progression. In this review, we discuss the mechanistic roles of the ERK subfamily members in EMT and tumor progression in diverse biological systems.
cancer, epithelial–mesenchymal transition (EMT), extracellular-signal regulated kinase (ERK), metastasis, phosphorylation
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Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
Int J Mol Sci. 2019 Jun 13;20(12). pii: ijms20122885. doi: 10.3390/ijms20122885. Link to article on publisher's site
International journal of molecular sciences
Olea-Flores M, Zuniga-Eulogio MD, Mendoza-Catalan MA, Rodriguez-Ruiz HA, Castaneda-Saucedo E, Ortuno-Pineda C, Padilla-Benavides T, Navarro-Tito N. (2019). Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer. Open Access Articles. https://doi.org/10.3390/ijms20122885. Retrieved from https://escholarship.umassmed.edu/oapubs/3883
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.