Title

Assessing the link between BACH1 and BRCA1 in the FA pathway

UMMS Affiliation

Department of Cancer Biology

Publication Date

12-17-2005

Document Type

Article

Subjects

Animals; BRCA1 Protein; Basic-Leucine Zipper Transcription Factors; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; Humans; Models, Biological

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The BACH1 helicase was initially identified by its direct binding to BRCA1 and, thus, was linked to hereditary breast cancer. More recently, BACH1 was identified as the gene defective in the J complementation group of Fanconi anemia (FA). FA is a multigenetic disorder characterized by cellular sensitivity to crosslinkers and chromosome instability. Because FANCD2 monoubiquitination is intact in BACH1 deficient cells, BACH1 appears to act downstream in the FA pathway akin to BRCA2/FANCD1. Interestingly, while BRCA1 has various interactions with FA proteins it has not been identified as an FA gene. As the race to uncover the last few unknown FA complementation groups comes to an end, future work will be required to uncover how these gene products function to combat the effects of DNA damage and maintain genomic stability. In particular, it remains elusive whether BRCA1 is functionally linked to the FA pathway through its interaction with BACH1/FANCJ. This review focuses on a model for the connection of BRCA1 to BACH1 in the FA pathway. We predict that BRCA1 regulates the BACH1 helicase activity to coordinate the timely displacement of Rad51 from nucleofilaments, promoting error free repair and ultimately maintaining chromosomal integrity.

Source

Cell Cycle. 2006 Jan;5(2):164-7. Epub 2006 Jan 16.

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

Related Resources

Link to article in PubMed

PubMed ID

16357529

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