UMMS Affiliation
Department of Population and Quantitative Health Sciences
Publication Date
2019-06-29
Document Type
Article
Disciplines
Epidemiology | Musculoskeletal Diseases | Musculoskeletal System | Radiology | Rheumatology
Abstract
BACKGROUND: To determine if adults with incident accelerated knee osteoarthritis (KOA) are more likely to have degenerative knee ligaments or tendons compared to individuals with typical or no KOA.
METHODS: We identified 3 sex-matched groups among Osteoarthritis Initiative participants who had a knee without radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2): 1) accelerated KOA: at least 1 knee had KL grade > /= 3 in < /=48 months, 2) typical KOA: at least 1 knee increased in radiographic scoring within 48 months, 3) no KOA: both knees had the same KL grade at baseline and 48 months. We evaluated knee magnetic resonance images up to 2 years before and after a visit when the accelerated or typical KOA criteria were met (index visit). Radiologists reported degenerative signal changes for cruciate and collateral ligaments, and extensor mechanism and proximal gastrocnemius tendons. We used generalized linear mixed models with 2 independent variables: group and time.
RESULTS: Starting at least 2 years before onset, adults with accelerated KOA were twice as likely to have degenerative cruciate ligaments than no KOA (odds ratio = 2.10, 95% CI = 1.18, 3.74). A weaker association (not statistically significant) was detected for adults with accelerated versus typical KOA (OR = 1.72, 95%CI = 0.99, 3.02). Regardless of time, adults with accelerated (odds ratio = 2.13) or typical KOA (odds ratio = 2.16) were twice as likely to have a degenerative extensor mechanism than no KOA. No other structural features were statistically significant.
CONCLUSIONS: Degenerative cruciate ligaments or extensor mechanism antedate radiographic onset of accelerated KOA. Hence, knee instability may precede accelerated KOA, which might help identify patients at high-risk for accelerated KOA and novel prevention strategies.
Keywords
Epidemiology, Knee, Ligaments, Osteoarthritis, Tendons
Rights and Permissions
© The Author(s). 2019 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI of Published Version
10.1186/s12891-019-2685-y
Source
BMC Musculoskelet Disord. 2019 Jun 29;20(1):308. doi: 10.1186/s12891-019-2685-y. Link to article on publisher's site
Journal/Book/Conference Title
BMC musculoskeletal disorders
Related Resources
PubMed ID
31253142
Repository Citation
Davis, Julie E.; Harkey, Matthew S.; Ward, Robert J.; MacKay, James W.; Lu, Bing; Price, Lori Lyn; Eaton, Charles B.; Lo, Grace H.; Barbe, Mary F.; McAlindon, Timothy E.; and Driban, Jeffrey B., "Accelerated knee osteoarthritis is associated with pre-radiographic degeneration of the extensor mechanism and cruciate ligaments: data from the Osteoarthritis Initiative" (2019). Open Access Articles. 3869.
https://escholarship.umassmed.edu/oapubs/3869
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Epidemiology Commons, Musculoskeletal Diseases Commons, Musculoskeletal System Commons, Radiology Commons, Rheumatology Commons