Switching on chromatin: mechanistic role of histone H4-K16 acetylation
Program in Molecular Medicine
Acetylation; Animals; Chromatin; Histones; Humans; Protein Binding; Transcription, Genetic
Life Sciences | Medicine and Health Sciences
How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.
Cell Cycle. 2006 Jul;5(13):1361-5. Epub 2006 Jul 1.
Cell cycle (Georgetown, Tex.)
Shogren-Knaak, Michael and Peterson, Craig L., "Switching on chromatin: mechanistic role of histone H4-K16 acetylation" (2006). Open Access Articles. 386.