UMMS Affiliation

Division of Hematology Oncology, Department of Medicine

Publication Date

2019-04-23

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Cells | Hemic and Immune Systems | Hemic and Lymphatic Diseases | Neoplasms | Therapeutics | Translational Medical Research

Abstract

Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs and developing effective, selective, and curative strategies through targeting LSCs. Here, we discuss LSCs in CML with a focus on identification of unique biological features of these stem cells to emphasize the feasibility and significance of specific targeting of LSCs while sparing normal stem cell counterparts in leukemia therapy.

Keywords

BCR-ABL, Bone marrow, Cancer stem cells, Chronic myeloid leukemia, Leukemia

Rights and Permissions

© 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.

DOI of Published Version

10.1002/sctm.18-0247

Source

Stem Cells Transl Med. 2019 Apr 23. doi: 10.1002/sctm.18-0247. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title

Stem cells translational medicine

Related Resources

Link to Article in PubMed

PubMed ID

31016860

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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