Exploiting Unique Biological Features of Leukemia Stem Cells for Therapeutic Benefit
UMass Chan Affiliations
Division of Hematology Oncology, Department of MedicineDocument Type
Journal ArticlePublication Date
2019-04-23Keywords
BCR-ABLBone marrow
Cancer stem cells
Chronic myeloid leukemia
Leukemia
Cancer Biology
Cell Biology
Cells
Hemic and Immune Systems
Hemic and Lymphatic Diseases
Neoplasms
Therapeutics
Translational Medical Research
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Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs and developing effective, selective, and curative strategies through targeting LSCs. Here, we discuss LSCs in CML with a focus on identification of unique biological features of these stem cells to emphasize the feasibility and significance of specific targeting of LSCs while sparing normal stem cell counterparts in leukemia therapy.Source
Stem Cells Transl Med. 2019 Apr 23. doi: 10.1002/sctm.18-0247. [Epub ahead of print] Link to article on publisher's site
DOI
10.1002/sctm.18-0247Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41046PubMed ID
31016860Related Resources
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© 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1002/sctm.18-0247
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Except where otherwise noted, this item's license is described as © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.